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Example sentences for: bdm

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One process inhibited by BDM is the centripetal flow of actin from the leading edge into the cell body, known as retrograde flow [ 11 12 ] . Retrograde flow is thought to be driven by a "push-pull" mechanism of polymerization of actin at the leading edge of the cell and contractile activity of myosin motor proteins [ 13 14 ] . Formation of new actin filaments is predominantly mediated by the nucleation activity of the Arp2/3 complex [ 15 ] . Members of the WASP/WAVE family of proteins, among others, stimulate and regulate the Arp2/3 complex for spatial and temporal control of filament nucleation [ 15 ] . Localization of these proteins to the leading edge, though not completely understood, is probably mediated through their interactions with the actin cytoskeleton itself and membrane-associated binding partners [ 15 16 ] .
So, is this effect that we see with BDM mediated by other proteins involved in retrograde flow?
BDM (Calbiochem 203984) stock solution was made in media at 0.5 M and Cytochalasin D (Sigma C8273) in DMSO at 20 mM.
After BDM treatment, we observed a uniform decrease in fluorescence suggestive of dissociation and diffusion of Arp3, rather than de-localization driven by retrograde flow [Figure 5A].
BDM treatment disrupted normal cellular distributions of maize myosins and the characteristic distribution of F-actin was also affected.