Example sentences for: az

How can you use “az” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • First, in a separate report, we showed that Smad1 itself is targeted to proteasome and is subsequently degraded by the proteasome, an event that is triggered by the activation of BMP type I receptor and involves the targeting role of Az and HsN3 [ 39 ] . Proteasomal degradation of Smad1 appears to also play a role in regulating the constitutive level of Smad1 in cell as a way to adjust the cellular responsiveness of BMPs [ 47 ] . However, the targeting mechanism and the regulation involved in these two cases of Smad1 degradation by proteasome are likely fundamentally different [ 39 ] . The second functional outcome of the physical link between Smad1, HsN3 and Az is the ability of Smad1 to regulate the proteasomal degradation of SNIP1, which is clearly dependent upon high levels of Smad1, Az and a strong activation signal from the type I receptor, as suggested by the observations that the protein levels of Smad1, Az and ALK3Q233D directly influence the degree of SNIP1 degradation.

  • Thus, we tested the hypothesis that Az and HsN3 also target Smad1 interacting proteins in the nucleus.

  • In a separate study, we have shown that Az and HsN3 play targeting roles in the proteasomal degradation of Smad1 upon the activation of BMP type I receptors [ 39 ] . The observed proteasomal degradation of Smad1 upon the activation of BMP signaling could simply serve to irreversibly terminate Smad1-mediated signaling pathways of BMPs.

  • The authors of this paper disclose their affiliations with Aventis (A), Abbott (AB), AstraZeneca (AZ), Bayer (B), Biovail (BV), Bristol-Myers Squibb (BMS), Forest (F), Glaxo-SmithKline/SmithKline Beecham (GSK/SKB), King Pharmaceuticals/Monarch (KM), Merck (M), Novartis (N), Nu-Pharm (NP), Pharmacia/Upjohn (PHU), Pfizer, Inc. (P), Sankyo (SY), Searle (SE), Solvay (SV), Takeda (T).

  • However, we observed that Az and HsN3 also interact with several isolated Smad1 interactors.

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