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Example sentences for: az
How can you use “az” in a sentence? Here are some example sentences to help you improve your vocabulary:
Cells were photographed digitally at a fixed exposure time by using a Photometrics CoolSNAP fx camera (Roper Scientific, Inc., Tucson, AZ) and the software MetaVue, Meta Imaging Series 4.5 (Universal Imaging Corporation, Downingtown, PA).
To systematically demonstrate the role of Smad1, Smad4 and Az in the observed decrease of SNIP1 protein level, we sequentially left out one of these three proteins in the above assay.
To confirm the interaction between SNIP1 and Az or HsN3 seen in the yeast two-hybrid system, we transfected COS1 cells with each pair of proteins and tested the interactions by immunoprecipitation assays.
First, in a separate report, we showed that Smad1 itself is targeted to proteasome and is subsequently degraded by the proteasome, an event that is triggered by the activation of BMP type I receptor and involves the targeting role of Az and HsN3 [ 39 ] . Proteasomal degradation of Smad1 appears to also play a role in regulating the constitutive level of Smad1 in cell as a way to adjust the cellular responsiveness of BMPs [ 47 ] . However, the targeting mechanism and the regulation involved in these two cases of Smad1 degradation by proteasome are likely fundamentally different [ 39 ] . The second functional outcome of the physical link between Smad1, HsN3 and Az is the ability of Smad1 to regulate the proteasomal degradation of SNIP1, which is clearly dependent upon high levels of Smad1, Az and a strong activation signal from the type I receptor, as suggested by the observations that the protein levels of Smad1, Az and ALK3Q233D directly influence the degree of SNIP1 degradation.
Blocking SNIP1 degradation was accompanied by increased protein levels of Smad1, Smad4 and Az in cells expressing the activated ALK3 (Fig.
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