Example sentences for: az

How can you use “az” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These relate to personal or institutional-affiliated receipt of income in the areas of research grants, consultant fees, or other compensation: BRD (AB,BMS,F,M,P,PHU,GSK/SKB), WCC (AZ,BMS,F,M,P,PHU,SY,SE,SV,T), JTW (A,B,BMS,F,KM, M,N,P), FHHL (AZ,B,BMS,M,NP,P,PHU), LJH (PHU); the other authors report no competing interests.

  • The Activation of the BMP type I receptor induces Smad1-dependent nuclear translocation of both HsN3 and Az

  • The 26S proteasome is responsible for the bulk turnover of cytoplasmic and nuclear proteins in eukaryotic cells and also plays a key role in the regulation of cell cycle, signal transduction, transcription as well as antigen presentation [ 17 18 19 20 21 ] . Most of the known proteasomal substrates are marked and targeted to proteasome by ubiquitination [ 17 19 20 ] . Ubiquitination, however, is not an obligatory step for substrate targeting to proteasome [ 17 18 20 ] . The degradation of the ornithine decarboxylase (ODC), the rate-limiting enzyme for polyamine synthesis, involves a protein named antizyme (Az), which binds and targets ODC to 26S proteasome for degradation [ 18 ] . However, ODC has remained an "orphan" in Az-dependent proteasomal degradation.

  • Az was previously identified as a polyamine-inducible factor that binds and targets the ornithine decarboxylase (ODC) to proteasome for degradation [ 18 45 ] . Until now, ODC is the only protein known to be targeted by Az to proteasome, although the existence of additional proteins targeted by Az to proteasome has been suspected [ 20 ] . We now find two new Az interactors: Smad1, the key signal transducer of BMPs, as well as SNIP1, the nuclear repressor of CBP/p300.

  • Az values by different observers for 188 sections were compared using non-parametric methods based on the Mann-Whitney statistics [ 20 ] . SAS statistical software (The SAS institute, Cary, NC) was implemented for this statistical analysis (Table 2).


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