Example sentences for: az

How can you use “az” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This report has focused upon the functional characterization of two proteins that function along the degradation pathways of the 26S proteasome: antizyme (Az) and HsN3.

  • The 26S proteasome is responsible for the bulk turnover of cytoplasmic and nuclear proteins in eukaryotic cells and also plays a key role in the regulation of cell cycle, signal transduction, transcription as well as antigen presentation [ 17 18 19 20 21 ] . Most of the known proteasomal substrates are marked and targeted to proteasome by ubiquitination [ 17 19 20 ] . Ubiquitination, however, is not an obligatory step for substrate targeting to proteasome [ 17 18 20 ] . The degradation of the ornithine decarboxylase (ODC), the rate-limiting enzyme for polyamine synthesis, involves a protein named antizyme (Az), which binds and targets ODC to 26S proteasome for degradation [ 18 ] . However, ODC has remained an "orphan" in Az-dependent proteasomal degradation.

  • These relate to personal or institutional-affiliated receipt of income in the areas of research grants, consultant fees, or other compensation: BRD (AB,BMS,F,M,P,PHU,GSK/SKB), WCC (AZ,BMS,F,M,P,PHU,SY,SE,SV,T), JTW (A,B,BMS,F,KM, M,N,P), FHHL (AZ,B,BMS,M,NP,P,PHU), LJH (PHU); the other authors report no competing interests.

  • Our VBA work was conducted at VBA's regional offices in Los Angeles, CA; Muskogee, OK; and Phoenix, AZ.

  • We next examined the interaction between Az and Smad1 in COS1 cells.


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