Words similar to attenuating
Example sentences for: attenuating
How can you use “attenuating” in a sentence? Here are some example sentences to help you improve your vocabulary:
Further, a mutant of Siah1a was constructed with the RING finger domain deleted, such that the protein was unable to act in the ubiquitin/proteasome pathway [ 46 ] . This deletion construct was as effective in attenuating group I mGluR function as the wild type Siah1a, providing supporting evidence that the effect of Siah1a resulted from its physical association with the receptors, rather than through a resulting reduction in receptor expression levels.
Such a mutant is inactive against exogenous substrates [ 34 35 36 ] . We found that this Src*/Cas(SD) molecule is constitutively tyrosine phosphorylated when expressed either transiently or stably in cells, and acts as a dominant negative mutant, attenuating v-crk mediated transformation when expressed in cells transformed by this oncogene.
Similarly, ligand-dependent targeted proteolysis of several nuclear receptors has been observed [ [ 39 40 41 42 ] ]. In the estrogen receptor, the RARα, and the RXRα, deletion of the α-helix H12 of the ligand binding domain which is essential for ligand-dependent activation stabilises these proteins showing that proteolysis and transactivation are intimately linked [ [ 42 43 44 ] ]. In the case of nuclear receptors, their targeted proteolysis in the presence of ligand may be a mechanism for attenuating the physiological response to the ligand.
I'm grateful to Daniel Radosh for filling in with disconcerting skill and to all of you for attenuating the pranks while he was the substitute.
Studies using knockout mice for each of these isoforms [ 9, 10, 11, 12] suggest that eNOS-derived NO is important in modulating basal pulmonary vascular tone, as well as in attenuating the development of pulmonary hypertension.
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