Words similar to attenuating
Example sentences for: attenuating
How can you use “attenuating” in a sentence? Here are some example sentences to help you improve your vocabulary:
I'm grateful to Daniel Radosh for filling in with disconcerting skill and to all of you for attenuating the pranks while he was the substitute.
Further, a mutant of Siah1a was constructed with the RING finger domain deleted, such that the protein was unable to act in the ubiquitin/proteasome pathway [ 46 ] . This deletion construct was as effective in attenuating group I mGluR function as the wild type Siah1a, providing supporting evidence that the effect of Siah1a resulted from its physical association with the receptors, rather than through a resulting reduction in receptor expression levels.
Similarly, ligand-dependent targeted proteolysis of several nuclear receptors has been observed [ [ 39 40 41 42 ] ]. In the estrogen receptor, the RARα, and the RXRα, deletion of the α-helix H12 of the ligand binding domain which is essential for ligand-dependent activation stabilises these proteins showing that proteolysis and transactivation are intimately linked [ [ 42 43 44 ] ]. In the case of nuclear receptors, their targeted proteolysis in the presence of ligand may be a mechanism for attenuating the physiological response to the ligand.
Such a mutant is inactive against exogenous substrates [ 34 35 36 ] . We found that this Src*/Cas(SD) molecule is constitutively tyrosine phosphorylated when expressed either transiently or stably in cells, and acts as a dominant negative mutant, attenuating v-crk mediated transformation when expressed in cells transformed by this oncogene.
Studies using knockout mice for each of these isoforms [ 9, 10, 11, 12] suggest that eNOS-derived NO is important in modulating basal pulmonary vascular tone, as well as in attenuating the development of pulmonary hypertension.
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