Words similar to atf-bpti

Example sentences for: atf-bpti

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The murinised version of ATF-BPTI differs by four amino acids from the human version It was shown to bind to the rat receptor and to inhibit plasmin activity in a rat model [ 21 ] . BPTI (commercialised as aprotinin) is a serine protease inhibitor prepared from bovine lung tissue which dose dependently inhibits human trypsin, plasmin and kallikrein.
In this extent, ATF-BPTI is similar to the MMPs inhibitors, in that their best indication would probably be for treatment of residual disease or small metastases.
The plasmid encoding the ATF-BPTI (pAB) was provided by P. Quax (TNO-PG, Leiden).
The murinised ATF-BPTI (mhAB) plasmid was constructed by an identical procedure, using the (Tyr22, Arg27,29,30) uPA mutant cDNA as starting sequence [ 33 ] .
The local delivery of the transgene in the tumour resulted in a low concentration of ATF-BPTI in the L44 tumour (60 - 90 ng / g tumour) and high concentration in the L42 tumours (1 - 1.4 μg / g tumour).