Words similar to atf-
Example sentences for: atf-
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The region designated as having HAT activity and containing the acetyltransferase domain shows poor conservation between orthologs and closely related paralogs of the ATF-2 family, especially in the sequence identified as the most prominent A motif of the acetyltransferase family (Figure 7).
ATF-2 is a basic leucine zipper (b-ZIP) family transcription factor that binds to cyclic AMP-response elements (CRE) and activates transcription [ 38].
In experiments designed to isolate ATF-2-associated HAT, ATF-2 alone was shown to be sufficient for the acetyltransferase activity.
Furthermore, complexity analysis using the SEG program, with the parameters adjusted for decomposition of a protein into globular and non-globular regions [ 41], predicted that the entire region of the ATF-2 protein between the amino-terminal zinc finger and the carboxy-terminal helical b-ZIP was unstructured.
Examining the region of ATF-2 that showed HAT activity, the authors found some sequence similarity and at least one motif resembling the acetyltransferase superfamily and concluded that ATF-2 contained a GCN5-like acetyltransferase domain [ 40].
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