Words similar to asp
Example sentences for: asp
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2B, the rate of the spontaneous inactivation of the inhibitor was significantly increased upon mutation: the functional half life of the mutants Asp355Pro, Arg356Pro and Pro357Gly was 23.
The biogerontologist David Sinclair and the bioethicist Leon Kass recently locked horns in a radio debate (http://www.theconnection.org/shows/2004/01/20040106_b_main.asp) on human life extension that was remarkable for one thing: on the key issue, Kass was right and Sinclair wrong.
Variations at residues alpha4 Thr183 and beta2 Ala135 generate different shapes of the binding pocket (Figure 4- Top), but preserve the electrostatic potential of the system: all non-conserved residues at position 183 are hydrophobic, and hydroxyl of Thr154 and Ser154 are superimposed, pointing away from the ligand, towards the carboxylate of Asp122.
1 sequence, include in sequential order: 1) A DxxTTxxDxxWR motif immediately preceding M1, 2) a highly conserved tryptophan in M1, 3) an insertion in the M1-P loop that contains a CVxx (V or I) motif, 4) the absence of an aromatic residue at the first 'aromatic cuff position [ 2 ] in the P segment helix, 5) a glutamine near the end of the P helix, 6) the absence of an aspartate at the end of the P segment signature sequence (TVGYGD) and a RxxTxxCP motif in the P-M2 loop that is two residues longer than in most other K +channels, 7) a glutamine in the first part of S6, and 8) a hydrophilic residue (Asn, Asp, or Glu) near the mid region of S6 that when negatively charged is involved in blockade of some Kir's by Mg 2+ [ 9 ] . Fig.
These results suggest that the role of the Asp355-Pro357 segment is to stabilize the inhibitory conformation of PAI-1.
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