Words similar to asparagine

Example sentences for: asparagine

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Several laboratories have shown that in addition to mutations in the N(T)KxD motif, which reduce overall nucleotide binding, dominant-negative Rab constructs can be generated by introducing amino acid substitutions ( e.g. , asparagine) at the position cognate to Ras S17 ( i.e. , S22 in Rab24) [ 31 40 41 42 ] . Such proteins are thought to be locked in an inactive GDP-bound state because the mutation markedly reduces their affinity for GTP, compared to GDP [ 42 ] . As shown in Fig.
In Rab24, and in some members of the Rho family, threonine occurs instead of the asparagine.
Mutation of Asp355 by asparagine (the non charged analog of aspartic acid), or by histidine or lysine (that have a positively charged side chain) or by alanine (neutral), inactivated PAI-1.
Comparison of the translated sequence to the GenBank database using the BLASTP program [ 34 ] revealed a significant match with human hnRNP A2/B1 [ 35 ] . The human and mouse proteins are identical except asparagine 287 in the human sequence was replaced by a threonine (Figure 1).
The distal ribbon is distorted by a large insert between the two core halves of the domain and a substitution of asparagine for one of the metal-coordinating cysteines.