Words similar to asparagine
Example sentences for: asparagine
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In contrast, the sequence specific HMG-box proteins have hydrophobic (V or I) and asparagine residues present at positions 5 and 10, respectively.
The asparagine at position 10 makes contact with DNA in the hSRY-DNA complex [ 24 ] , as does the serine at this position in the NHP6A-DNA complex [ 7 ] . A hydrophobic residue at position 32 that can partially intercalate into DNA plays a role in DNA binding of some sequence-independent HMG-box proteins [ 7 25 26 ] . Position 32 is the hydrophobic residue phenylalanine in TOX, in contrast to the polar residues found at this position in SRY, SOX proteins and LEF-1.
Comparison of the translated sequence to the GenBank database using the BLASTP program [ 34 ] revealed a significant match with human hnRNP A2/B1 [ 35 ] . The human and mouse proteins are identical except asparagine 287 in the human sequence was replaced by a threonine (Figure 1).
Mutation of Asp355 by asparagine (the non charged analog of aspartic acid), or by histidine or lysine (that have a positively charged side chain) or by alanine (neutral), inactivated PAI-1.
In all of the known Ras-related GTPases the guanine nucleotide binding site is surrounded by a set of highly conserved sequence elements [ 33 34 ] . One of these elements, termed the G2 motif, consists of NKxD (with the asparagine located at position 116 in H-Ras).