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Example sentences for: asn
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Two-thirds of all sequenced metallo-β-lactamases have an Asn at position 233 [ 41 ] , and this residue was predicted [ 42 ] and shown [ 43 ] to be involved with substrate binding and activation by interacting electrostatically with the substrate β-lactam carbonyl.
In all the available organisms, the four central protomers of the midasin polypeptide, AAA2, AAA3, AAA4 and AAA5, possess canonical Walker A and B motifs, as well as the critical Asn in sensor 1 and Arg in sensor 2 that are required for proper function in other AAA proteins [ 15 ] . The presence of these critical residues, taken together with their higher level of average sequence conservation (Table 1), suggests that the four central protomers all retain an active enzymatic function.
Tumor suppression by Fhit is not destroyed by mutation of the nucleophilic His96 to Asn, a mutation that specifically reduces k cat [ 2 12 ] . Thus, evidence suggests that the proapoptotic function of Fhit depends on formation of an E-S complex.
Mutation of Asn122 to Asp by site-directed mutagenesis destroyed the phosphatase activity, confirming the essential role of this residue of PP1 in catalysis [ 19 ] . PfPP1 was inhibited by NaF, inorganic orthophosphate, and pyrophosphate at respective IC 50 values of 2.5 mM, 10 mM, and 90 μM (data not shown).
Less strong Lewis bases are the charge-compensated Glu in an ion-pair with Arg, the amide group of Gln and Asn, and finally the carbonyl of the peptide backbone as the weakest [ 29 ] . The importance of the ligand was demonstrated by substitution of His with the weaker Lewis base Asn in the apoprotein of the bacterial light-harvesting complex LH1, which eliminated assembly of the complex in vivo and reconstitution in vitro [ 30 ] . Formation of a stable coordination bond with a weaker Lewis base is expected to require a stronger Lewis acid.
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