Example sentences for: asd

How can you use “asd” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In this study, we analyzed mice heterozygous for a null allele of Bmp4 ( Bmp4 tmlBlh ) [ 24 ] to determine if decreased functional gene dosage contributes to ASD and elevated IOP.

  • The abnormalities affect a variety of anterior segment tissues including the drainage structures of the iridocorneal angle and are similar to those reported in human patients with ASD and glaucoma [ 36 37 38 ] . The absence of detectable Bmp4 expression in the drainage structures suggests that BMP4 produced by the ciliary body and/or iris may act as a growth and differentiation factor during angle development.

  • For FOXC1 and PAX6, both haploinsufficiency and increased gene dosage due to gene duplication result in abnormal ocular development [ 10 11 12 13 ] . Similarly, a mutation in PITX2 that results in increased transcriptional transactivation causes ASD [ 14 ] .

  • Heterozygous Bmp4 mutant mice have a variety of ocular abnormalities including ASD, buphthalmia (enlarged eyes), and elevated IOP.

  • In humans with ASD, the phenotype is variable even between patients with mutations in the same gene, and the severity of clinically observable dysgenesis does not correlate with IOP.


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