Words similar to ascr

Example sentences for: ascr

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There is no evidence that the ASCR domain in the DDRP α-subunits binds nucleic acids and studies on SUI1 protein and the arginine repressor ligand-binding domain implicate the ASCR domain in protein-protein interactions and small molecule binding [ 77 79 ] . However, most of the ASCR domains are present in proteins that interact with nucleic acids (see above), raising the possibility of a role in non-specific nucleic acid binding.
The ASCR domains of bacterial α-subunits and eukaryotic RBP3 share a common insert domain between helix-1 and strand 3, which apparently has been lost in the RBP11 subunit of the eukaryotic DDRPs.
This was followed by the insertion of the ASCR domain, which probably evolved as a result of a duplication of the RBP3/11 subunits, into this RRM-like domain.
Mirroring the insertion of the ASCR domain in the β' subunit, a distinct α + β globular domain, N-terminal to the DPBB domain (region 578-632 of 1K83, Chain B), is inserted in the β subunits of all archaeal and eukaryotic DDRPs (Fig.
Both the spatial arrangement of the ASCR domain in the β' subunits and its extreme sequence divergence with respect to the ASCR domains of the α-subunit suggests that it has acquired a new function.