Words similar to arsenate
Example sentences for: arsenate
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For example, the arsC sequences from major divisions of Bacteria such as the Green Sulfur Bacteria (represented by Chlorobium tepidum ) and the Deinococcales (represented by D. radiodurans ) are loosely associated with either the Enterobacteriales/α-Proteobacteria (Figure 2) or Low GC Gram-positive Bacteria (Figure 3) depending upon the analysis used, but in either case diverge to form their own deep branches, suggesting that they possess distinct arsenate reductases.
Amino acid sequences of the confirmed bacterial arsenate reductases (12 total) were initially aligned automatically using the Fast Aligner function of ARB Edit 4.1, and then manually adjusted to ensure that secondary structure considerations of the arsenate reductase protein were met.
Despite the suggestion of HGT and duplication events, the arsC phylogeny suggests that arsenate reductase is an evolutionarily old enzyme, a hypothesis that was recently suggested for arsenite oxidase [ 38 ] . This is the first phylogenetic analysis of an arsenic redox active gene to include all three domains and the Archaea and Bacteria were clearly separated, with S. cerevisiae subsequently branching from Archaea.
Recent ideas on the origin of life suggest that early cellular structures were abiotic iron-sulfur formations at submarine hydrothermal vents in the Hadean ocean, in which basic biochemical and metabolic processes could have developed before the formation of cell membranes [ 39 40 ] . As well as iron and sulfur, hydrothermal areas are often are often characterized by high levels of arsenic [ 41 ] and may even contain arsenic redox active microbial communities [ 42 ] . Given the integral role of phosphate in early (and current) cellular metabolism [ 39 ] , an ability to reduce the levels of arsenate (a phosphate analog) might have been an essential biochemical process.
The arsC sequence of C. acetobutylicum is typical of the clostridial arsC genes, and also shows some similarity to the arsenate reductase sequence in L. interrogans (a Spirochete).
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