Words similar to arsenate
Example sentences for: arsenate
How can you use “arsenate” in a sentence? Here are some example sentences to help you improve your vocabulary:
The ars operon consists of a group of genes coding for a transmembrane pump and an arsenate reductase ( arsC ). The operon includes a regulatory gene ( arsR ) and a gene coding for an arsenite-specific pump ( arsB ) as well as arsC [ 13 ] . Arsenite is pumped directly out of the cell by the arsB protein; however arsenate must first be reduced to arsenite by the cytoplasmic arsenate reductase coded from arsC . Some bacteria also possess other ars genes: arsA produces an arsenite-stimulated ATPase [ 14 ] that results in more efficient arsenite extrusion; arsD encodes for a regulatory protein that controls the upper level of ars expression [ 15 ] ; arsH has been identified but has an uncertain function [ 16 ] . The ars operon was initially recognized in plamids of Staphylococcus aureus and S. xylosus [ 17 18 ] but has subsequently been found in other microorganisms (e.g.
The arsC sequence of C. acetobutylicum is typical of the clostridial arsC genes, and also shows some similarity to the arsenate reductase sequence in L. interrogans (a Spirochete).
Inorganic arsenic exists primarily in two valence states: arsenite (As III ) and arsenate (As V , or the arsenate ion AsO 4 3-).
Two of these classes are bacterial (one typified by the arsC found in enteric bacteria such as E. coli ; the other typified by the arsC found in Staphylococcus plasmids and other Gram-positive Bacteria); the third is the Arr2 gene of S. cerevisiae . Phylogenies of these gene families based on 18 arsC sequences were recently reported [ 30 ] . However, as well as microorganisms that have been shown to have demonstrable arsenate resistance, whole genome analyses of various microorganisms have revealed an increasing number of open reading frames (ORFs) that have homology to arsC . Inclusion of these putative arsC genes in phylogenetic analyses might resolve the basic question: Did arsenate resistance systems evolve from a common origin or develop convergently in multiple taxa?
Both forms are toxic to microorganisms, with arsenite disrupting enzyme function, and arsenate behaving as a phosphate analog and interfering with phosphate uptake and utilization [ 1 ] . Microorganisms have evolved a variety of mechanisms for coping with arsenic toxicity, including minimizing the amount of arsenic that enters the cell (e.g.
Loading...