Words similar to arp
Example sentences for: arp
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Two possible mechanisms for Arp2/3 complex de-localization were considered: Arp2/3 could move back from the leading edge with retrograde flow of actin and then be lost from the filaments, or it could simply diffuse from the leading edge.
Experimental approaches that may help address how such a dynamic and sensitive structure is established and maintained include combining inhibition of actin dynamics with the use of tools that affect Arp2/3 or myosin activity or localization, in specific ways.
After BDM treatment, we observed a uniform decrease in fluorescence suggestive of dissociation and diffusion of Arp3, rather than de-localization driven by retrograde flow [Figure 5A].
In fact, Arp3 staining at the leading edge was consistently higher.
One process inhibited by BDM is the centripetal flow of actin from the leading edge into the cell body, known as retrograde flow [ 11 12 ] . Retrograde flow is thought to be driven by a "push-pull" mechanism of polymerization of actin at the leading edge of the cell and contractile activity of myosin motor proteins [ 13 14 ] . Formation of new actin filaments is predominantly mediated by the nucleation activity of the Arp2/3 complex [ 15 ] . Members of the WASP/WAVE family of proteins, among others, stimulate and regulate the Arp2/3 complex for spatial and temporal control of filament nucleation [ 15 ] . Localization of these proteins to the leading edge, though not completely understood, is probably mediated through their interactions with the actin cytoskeleton itself and membrane-associated binding partners [ 15 16 ] .
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