Words similar to aptazyme

Example sentences for: aptazyme

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These levels of ligand-dependent activation were similar to those observed with the original hammerhead aptazyme constructs, [ 21 ] and it may prove possible to use in vitro selection to further optimize activation [ 13 14 ] . However, when the time course data were fit with a single exponential equation, the rates of the initial reactions turned out to be very similar in both the presence and absence of theophylline (Table 2).
Interestingly, those aptazyme constructs that showed ligand-dependent activity closely resembled the original deletion variants that showed magnesium-dependent recovery of splicing activity.
In order to convert the Group I self-splicing intron to a regulatable aptazyme, it was necessary to first identify sequences or structures in the ribozyme whose conformation might modulate splicing activity.
The parental P6 aptazyme construct was generated by two overlapping oligos, Gp1Wt2 Gp1Wt2.
Similar results were obtained with cultures that contained the td gene divided by the aptazyme Th1P5 (Figure 4b).