Words similar to aptazyme

Example sentences for: aptazyme

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In contrast, the original aptamer was known to also bind 3-methylxanthine, and the original Group I aptazyme (Th2P6) also proved to be responsive to 3-methylxanthine in vivo (Figure 6c).
The ligand specificity of the anti-theophylline aptamer carried over to the theophylline-dependent aptazyme, and no activation was seen with caffeine, which differed by a single methyl group from theophylline.
[ 22 23 24 25 26 ] Therefore, it was possible that theophylline-binding influenced the overall folding pathway of the engineered Group I aptazyme.
Interestingly, no growth was observed for bacteria harboring the intron Th1P6, despite the fact that this aptazyme showed the greatest activation by theophylline in vitro . The plating results were consistent and reproducible over a variety of experiments.
Interestingly, those aptazyme constructs that showed ligand-dependent activity closely resembled the original deletion variants that showed magnesium-dependent recovery of splicing activity.