Words similar to aptazyme

Example sentences for: aptazyme

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In contrast, the original aptamer was known to also bind 3-methylxanthine, and the original Group I aptazyme (Th2P6) also proved to be responsive to 3-methylxanthine in vivo (Figure 6c).
Similarly, it may prove possible to use effector-dependent splicing to more finely monitor gene expression in vivo . A drug could be localized to particular organs, cells, or organelles, and splicing of the aptazyme could be monitored via a reporter gene such as luciferase.
The ligand specificity of the anti-theophylline aptamer carried over to the theophylline-dependent aptazyme, and no activation was seen with caffeine, which differed by a single methyl group from theophylline.
In order to convert the Group I self-splicing intron to a regulatable aptazyme, it was necessary to first identify sequences or structures in the ribozyme whose conformation might modulate splicing activity.
[ 22 23 24 25 26 ] Therefore, it was possible that theophylline-binding influenced the overall folding pathway of the engineered Group I aptazyme.