Words similar to aptazyme

Example sentences for: aptazyme

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Similarly, it may prove possible to use effector-dependent splicing to more finely monitor gene expression in vivo . A drug could be localized to particular organs, cells, or organelles, and splicing of the aptazyme could be monitored via a reporter gene such as luciferase.
The parental P6 aptazyme construct was generated by two overlapping oligos, Gp1Wt2 Gp1Wt2.
Finally, no growth was observed in a negative control that contained a non-functional Group I intron (B11), and no theophylline-dependent changes in growth were observed in a negative control in which mutations were introduced into the aptazyme to abolish theophylline binding (Th2P6.D).
An overnight bacterial culture that contained the td gene divided by the aptazyme Th2P6 was inoculated into fresh, minimal media, effector was added, and growth was continuously monitored.
For example, the junction between the aptamer and the Group I ribozyme in the aptazyme Th2P6 resembled the deletion variant td ΔP6-6; the aptazyme was activated by theophylline, while the splicing defect of the deletion variant at 3 mM magnesium was suppressed by 8 mM magnesium or by stabilization of a tetraloop sequence that capped the P6 helix [ 15 ] . Defects that poise a ribozyme between active and inactive conformers have previously been used to engineer effector-dependence [ 20 ] .