Example sentences for: antimuscarinic

How can you use “antimuscarinic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 6 ng/ml plasma concentration [ 22 23 24 ] ) is greater than the first dose observed to produce significant peripheral antimuscarinic effects in this study (1.

  • Olanzapine therapy is associated with a number of side effects, including somnolence, agitation, nervousness, headaches, dizziness, weight gain, constipation and dry mouth [ 5 ] . Olanzapine, however, does not produce extrapyramidal side effects, postural hypotension or hemotoxicity (a particular problem for patients on clozapine therapy [ 13 ] ). Although urinary retention as a result of olanzapine therapy may be predicted from binding studies due to olanzapine's antimuscarinic activity [ 12 ] only 1 case report of micturition disturbance associated with olanzapine has recently appeared [ 14 ] . On the other hand, several reports of urinary disturbances due to clozapine can be found in the clinical literature [ 3 10 15 ] .

  • Risperidone provides an interesting comparison to olanzapine since it has a similar pharmacological profile to olanzapine but without the antimuscarinic activity.

  • Since the contraction pressures observed during cystometry were smaller than those observed after electrical stimulation of the pelvic nerve (and against a closed urethra) it is possible that the antimuscarinic effects of clozapine on bladder contraction pressure are not detected because during cystometry maximal bladder pressures are not necessary for emptying.

  • A direct inhibitory action of olanzapine on the EUS muscle itself is not expected and was not seen with clozapine [ 7 ] . However, antimuscarinic effects alone cannot account for all of the effects of olanzapine on the EUS, since risperidone had a similar effect although not quite as pronounced and risperidone has little or no affinity for muscarinic receptors [ 16 ] . Therefore, antagonism of other transmitter systems, e.g.


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