Words similar to antimitotics
Example sentences for: antimitotics
How can you use “antimitotics” in a sentence? Here are some example sentences to help you improve your vocabulary:
Common agents currently used in treating metastatic breast cancer are the antimitotics paclitaxel and docetaxel [ 1 2 ] . These drugs bind to β-tubulin, a major protein in mitotic spindles, and halt cell division at metaphase.
In ovarian cancer cells, mutations in residues near the putative paclitaxel-binding site of β-tubulin class I were found in paclitaxel-resistant ovarian cancer cells [ 23 ] . Other work suggests that changes in tubulin isotypes alone cannot confer resistance to antimitotics.
The major differences between isotype classes reside in the last 15-20 amino acids of the carboxy-termini [ 10 11 ] , and these differences have been exploited in the development of isotype-specific antibodies [ 12 13 14 ] . Mammalian microtubules are formed from a mixture of α-tubulin and β-tubulin isotype classes [ 11 15 16 ] , and the antimitotics used in chemotherapy interact primarily with β-tubulin.
The expression of genes encoding α-tubulin and β-tubulin seems to be developmentally regulated [ 19 ] . For example, tubulin isotype expression patterns change during the development and maturation of neurons [ 14 20 ] . Studies with paclitaxel or other antimitotic agents, such as colchicine or estramustine, indicate that drug interactions with tubulin isotypes differ [ 21 22 23 24 25 ] and might contribute to cell resistance to antimitotics [ 26 27 28 29 30 31 ] . However, one group of antimitotic agents, the vinca alkaloids, was shown to bind with similar affinity to all tubulin isotypes [ 12 ] , suggesting that alterations in drug binding affinity is unlikely to be the cause of drug resistance.
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