Words similar to antimitotics
Example sentences for: antimitotics
How can you use “antimitotics” in a sentence? Here are some example sentences to help you improve your vocabulary:
The expression of genes encoding α-tubulin and β-tubulin seems to be developmentally regulated [ 19 ] . For example, tubulin isotype expression patterns change during the development and maturation of neurons [ 14 20 ] . Studies with paclitaxel or other antimitotic agents, such as colchicine or estramustine, indicate that drug interactions with tubulin isotypes differ [ 21 22 23 24 25 ] and might contribute to cell resistance to antimitotics [ 26 27 28 29 30 31 ] . However, one group of antimitotic agents, the vinca alkaloids, was shown to bind with similar affinity to all tubulin isotypes [ 12 ] , suggesting that alterations in drug binding affinity is unlikely to be the cause of drug resistance.
Common agents currently used in treating metastatic breast cancer are the antimitotics paclitaxel and docetaxel [ 1 2 ] . These drugs bind to β-tubulin, a major protein in mitotic spindles, and halt cell division at metaphase.
In ovarian cancer cells, mutations in residues near the putative paclitaxel-binding site of β-tubulin class I were found in paclitaxel-resistant ovarian cancer cells [ 23 ] . Other work suggests that changes in tubulin isotypes alone cannot confer resistance to antimitotics.
The major differences between isotype classes reside in the last 15-20 amino acids of the carboxy-termini [ 10 11 ] , and these differences have been exploited in the development of isotype-specific antibodies [ 12 13 14 ] . Mammalian microtubules are formed from a mixture of α-tubulin and β-tubulin isotype classes [ 11 15 16 ] , and the antimitotics used in chemotherapy interact primarily with β-tubulin.
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