Words similar to antimitotic
Example sentences for: antimitotic
How can you use “antimitotic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Over the past decade paclitaxel and docetaxel have become important chemotherapeutic agents for both ovarian and breast cancers [ 1 2 ] . Considerable interest has focused on the target receptor - tubulin - and mechanisms underlying efficacy, toxicity, and drug resistance [ 7 8 23 24 27 28 ] . Whether tubulin isotype levels might determine cellular responses to antimitotic agents remains controversial.
It was demonstrated that one group of antimitotic agents, vinca alkaloids, bind with similar affinity to all β-tubulin isotypes [ 12 ] , thus suggesting for therapy with vinorelbine, vinblas-tine, or vincristine that tubulin isotype levels are incidental for efficacy.
In most experiments, endogenous non-neuronal cells were eliminated from cultures by adding cytosine-β-D-arabinofuranoside (Sigma, St. Louis, MO) to the culture medium at 1 μM for 48 hr beginning on day 2. In some experiments this antimitotic was not added to cultures but rather endogenous non-neuronal cells were allowed to proliferate.
This work fulfills their suggestion to quantify changes in tubulin isotype levels with the appropriate antibodies, and establishes a sensitive and accurate assay to complement mRNA assays and studies of the response of cultured cells to antimitotic drugs.
Nevertheless, we cannot exclude the possibility that changes in the distribution of tubulin isotypes in normal and tumor breast tissue, in conjunction with other molecular factors, might still be relevant to disease progression and cellular response to antimitotic drugs.
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