Example sentences for: antimitotic

How can you use “antimitotic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This work fulfills their suggestion to quantify changes in tubulin isotype levels with the appropriate antibodies, and establishes a sensitive and accurate assay to complement mRNA assays and studies of the response of cultured cells to antimitotic drugs.

  • Nevertheless, we cannot exclude the possibility that changes in the distribution of tubulin isotypes in normal and tumor breast tissue, in conjunction with other molecular factors, might still be relevant to disease progression and cellular response to antimitotic drugs.

  • Furthermore, transfection of CHO cells with β-tubulin classes I, II, or IVb did not produce resistance to paclitaxel [ 32 ] . The alternative hypothesis, derived from the work of Cabral and colleagues, is that rather than the tubulin isotype levels, the amount of polymerized tubulin is the critical factor that regulates response to antimitotic drugs.

  • Over the past decade paclitaxel and docetaxel have become important chemotherapeutic agents for both ovarian and breast cancers [ 1 2 ] . Considerable interest has focused on the target receptor - tubulin - and mechanisms underlying efficacy, toxicity, and drug resistance [ 7 8 23 24 27 28 ] . Whether tubulin isotype levels might determine cellular responses to antimitotic agents remains controversial.

  • The β-tubulin isotype levels in normal and tumor tissue are not significantly different and are therefore unlikely to contribute to differential responses of tumors to antimitotic agents.


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