Words similar to antigen-presenting
Example sentences for: antigen-presenting
How can you use “antigen-presenting” in a sentence? Here are some example sentences to help you improve your vocabulary:
IL-10, a cytokine produced by activated macrophages and Th2-type T cells, has crucial inhibitory effect against several Th-1 type immune responses, such as the antigen-presenting functions of monocytes and macrophages [ 52 53 ] . IL-10 may play an important role in preventing the induction of IBD, since animals deficient in IL-10 will develop colitis spontaneously, and low levels of IL-10 are positively correlated with recurrences of Crohn's disease [ 25 54 ] . However, unlike TNF-α based therapies, the administration of recombinant IL-10 (rIL-10) shows poor clinical efficacy.
CD1a is expressed in differentiated antigen-presenting cells and monocytes and is used as a marker for the presence of these cells in the skin [ 24 25 26 ] . The CD1 molecules are the products of five CD1 genes located on chromosome 1. The genes are closely related to the mixed histocompatibilty complex (MHC) genes indicating origin from a common precursor [ 27 ] . CD1 molecules, however, have limited sequence homology to MHC class I and II molecules, and unlike the MHC molecules are also capable of binding non-protein antigens [ 28 29 ] .
These differentiated cells, although usually stable, sometime exhibit proliferative activity and increase in many cutaneous immune response states [ 23 39 40 ] . The inability of PTU to reduce CD1a expression in biopsy samples of patients with psoriasis suggests that the mechanism of action of this drug is psoriasis is not due to any effect on skin antigen-presenting cells or production of IL-12, a motive cytokine that is responsible for initiation and maintenance of the cytokine stimulatory cascade that leads to formation of the psoriatic plaque [ 16 ] . In support of this argument is the fact that circulating IL-12 did not show any significant change with PTU treatment (submitted).
B7-1) on tumor cells [ 45 ] . Radiation has been shown to increase the expression of MHC class I and II molecules in tumor cell lines [ 46 47 ] . Thus, the tissue damage signals evoked by ionizing radiation may trigger the activation and infiltration of antigen-presenting cells, in particular dendritic cells [ 38 48 49 50 ] . Indeed, in the regression study, we observe some increase of tumor-infiltrating dendritic cells in the group receiving the single radiation treatment.
For some experiments, the transduced cells were then activated with 5 μM ionomycin and 50 ng/ml PMA for 4 h or stimulated for 18 h by immobilized anti-CD3 (pre-coated at 10 μg/ml in PBS) or 5 μg/ml OVA peptide with antigen-presenting cells before analysis.
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