Words similar to antigen-presenting
Example sentences for: antigen-presenting
How can you use “antigen-presenting” in a sentence? Here are some example sentences to help you improve your vocabulary:
IL-10, a cytokine produced by activated macrophages and Th2-type T cells, has crucial inhibitory effect against several Th-1 type immune responses, such as the antigen-presenting functions of monocytes and macrophages [ 52 53 ] . IL-10 may play an important role in preventing the induction of IBD, since animals deficient in IL-10 will develop colitis spontaneously, and low levels of IL-10 are positively correlated with recurrences of Crohn's disease [ 25 54 ] . However, unlike TNF-α based therapies, the administration of recombinant IL-10 (rIL-10) shows poor clinical efficacy.
Skin antigen-presenting cells (Langerhans cells) appear to play an important role in the initiating events that lead to the cytokine cascade that results in keratinocyte proliferation and development of psoriatic lesions [ 16 17 18 ] . Effective therapeutic approaches to psoriasis treatment, such as psoralen UV-A therapy (PUVA), which result in depletion of APCs in the skin [ 19 20 ] , and UV-B [ 21 ] , lead to one of the most sustained improvement in psoriasis.
An additional concern was that IFN-γ-producing effector cells might inhibit potential IL-4 precursors from differentiating or expanding in these cultures, although previous studies [ 29, 30, 31] demonstrated that IFN-γ indirectly affected the generation of IL-4-secreting cells through the activities of antigen-presenting cells.
It is notable that the functional groups identified in this list of genes significantly induced after infection of professional antigen-presenting cells are related to immune responses.
CD1a is expressed in differentiated antigen-presenting cells and monocytes and is used as a marker for the presence of these cells in the skin [ 24 25 26 ] . The CD1 molecules are the products of five CD1 genes located on chromosome 1. The genes are closely related to the mixed histocompatibilty complex (MHC) genes indicating origin from a common precursor [ 27 ] . CD1 molecules, however, have limited sequence homology to MHC class I and II molecules, and unlike the MHC molecules are also capable of binding non-protein antigens [ 28 29 ] .
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