Words similar to antigen-induced
Example sentences for: antigen-induced
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We have also investigated whether mactinin is present in the antigen-induced arthritis model in rabbits [ 13 14 ] . Macrophages are believed to be important in this model of rheumatoid arthritis [ 15 16 ] , and both the arthritic and control joint fluid can be tested for mactinin.
To produce antigen-induced arthritis, New Zealand white rabbits were immunized by subdermal injection of ovalbumin emulsified in complete Freund's adjuvant in accordance with modifications [ 14 ] of the method of Dumonde and Glynn [ 13 ] under IACUC approval.
Measurement of mactinin in the antigen-induced arthritis model
The antigen-induced arthritis model of rheumatoid arthritis in rabbits demonstrates persistent active inflammation for several months after the intra-articular injection of antigen, including hypertrophy and hyperplasia of the synovial lining cells, pannus formation with articular cartilage erosion, and chronic infiltration of synovium by lymphocytes and plasma cells [ 13 ] . In addition, Dijkstra and colleagues [ 15 ] found macrophages in the superficial layer of the synovium, where they might secrete enzymes and oxygen radicals into the joint space, which can lead to cartilage erosion [ 9 ] . The protein levels in lavage fluid from arthritic joints in this model are low enough to allow direct testing by Western blot analysis without immunoaffinity purification, as was needed with the human aspirates.
The overall effect of urokinase in the antigen-induced arthritis model seems to be beneficial, because chronic joint inflammation and bone erosion are significantly worse in urokinase-deficient mice [ 30 ] . However, the ability of urokinase-generated mactinin to enhance proteolysis might be deleterious.
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