Example sentences for: antifibrotic

How can you use “antifibrotic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Prostanoids are important regulators of fibroblast function [ 5 6 7 8 9 ] . Prostaglandin (PG)E 2 is thought to have antifibrotic properties in vitro , but also can have proinflammatory effects both in vivo and in vitro [ 10 11 12 ] . Thromboxane (TX)A 2 increases proliferation, and DNA and RNA synthesis in several cell types, including fibroblasts and smooth muscle like glomerular mesangial cells [ 13 14 15 16 ] . Conversely, prostacyclin (PGI 2 ) decreases smooth muscle cell proliferation and collagen synthesis [ 17 18 ] .

  • Many cell types, including lung fibroblasts, contain cyclooxygenase (COX), a proximal enzyme in prostanoid production, and can generate prostanoids [ 19 ] . It has been previously reported that IPF lung fibroblasts have decreased COX-2 expression compared to normal lung fibroblasts and, hence, have decreased PGE 2 production [ 12 20 21 ] . Because of these findings and the fact that PGs are important fibroblast regulators, we sought to investigate whether abnormalities in COX-2 expression could be associated with an altered balance between profibrotic and antifibrotic PGs.

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