Example sentences for: antiestrogens

How can you use “antiestrogens” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Thus, part of the chemopreventive efficacy of antiestrogens and retinoids in this model may be due to a generalized decrease in ductal development.

  • There is an extensive literature showing that steroid hormone superfamily members, such as antiestrogens and retinoids, can upregulate TGF-β activity in a variety of systems [ 12, 13, 14, 15, 16, 17, 23, 24, 35].

  • Antiestrogens such as tamoxifen have been shown to upregulate TGF-β production and activation by many cell types, including human breast cancer cell lines [ 12, 13, 14, 15].

  • Obesity is also associated with significant hormonal changes such as decreased serum estradiol and sex hormone binding globulin (SHBG) levels, increased peripheral fat conversion of estrogens to progesterone and increased serum testosterone levels that may be associated with an increased risk of breast cancer [ 17 ] . Estrogens are necessary for normal breast development, and they induce and promote mammary tumor growth in animal studies [ 18 ] . In addition, the close association between increased risk of breast cancer and certain reproductive factors such as early menarche and late menopause [ 19 ] , as well as the fall off in the rate of increase in the incidence of disease at menopause [ 20 ] and the lowered risk of breast cancer in oophorectomized women and those taking antiestrogens [ 21 22 ] , all support the role of estrogen in breast carcinogenesis.

  • Part of the chemopreventive efficacy of antiestrogens and retinoids in this model may therefore be due to a generalized decrease in ductal development.


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