Words similar to analgesics
Example sentences for: analgesics
How can you use “analgesics” in a sentence? Here are some example sentences to help you improve your vocabulary:
Onset of analgesia with rofecoxib 50 mg appeared to be generally the same as with comparator analgesics.
Our data clearly show that nalbuphine is a potent agonist at the μ opioid receptor with an efficacy similar to that of morphine, thus agreeing with in vivo data showing that morphine and nalbuphine are equally potent as analgesics [ 33 ] . However, other reports have described nalbuphine as a "mixed agonist/antagonist" with agonism at κ opioid receptors and antagonism at μ opioid receptors based on in vivo data [ 11 33 ] . This categorization is likely due to the fact that nalbuphine has been shown to reduce the ventilatory depressant effect of other opioids, while adding to their analgesic effect [ 33 ] . Nalbuphine is also used clinically to reduce the opioid-mediated side effects such as itching, without completely reversing the analgesic effects of the full agonists [ 34 35 36 ] . According to our data, although nalbuphine is clearly a potent agonist at μ receptors, its levels of agonism is significantly lower than the very efficacious drug fentanyl and the endogenous ligand β-endorphin.
In 1986, the World Health Organization (WHO) developed a 3-step conceptual model to guide the management of cancer pain (see Figure 1) [ 25 ] . It provides a simple, well-tested model to guide the initial selection, administration, and titration of analgesics to manage the pain associated with any serious illness.
There is evidence suggesting that δ selective opioid ligands do not cause changes in respiratory parameters [ 13 ] . Thus, suggesting that designing specific ligands that act at δ opioid receptors may be useful in formulating analgesics without the side effect of ventilatory depression.
The extended time to remedication for rofecoxib 50 mg may represent a real clinical advantage where the problem is not a lack of effective analgesics, but rather effective analgesics ineffectively delivered [ 35 ] , and given that using a relatively large dose has no disadvantages.
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