Example sentences for: analgesics

How can you use “analgesics” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Still, other reports, have suggested that opioid ligands with agonistic effect at μ opioid receptors and antagonistic effect at δ opioid receptors are potentially useful analgesics [ 3 17 18 ] . These latter results advocate that the key to designing opioid ligands with optimal analgesia and minimal side effects may be in the design of ligands that act on more than one receptor type, but activate each receptor differently.

  • Clinical trials in acute pain normally last four to six hours, because that is the duration of effect for most analgesics, whether injected or as tablets, and for simple analgesics, NSAIDs or opioids.

  • Step 2 and 3 analgesics include the pure agonist opioids, eg, codeine, fentanyl, hydrocodone, hydromorphone, morphine, and oxycodone.

  • Our data clearly show that nalbuphine is a potent agonist at the μ opioid receptor with an efficacy similar to that of morphine, thus agreeing with in vivo data showing that morphine and nalbuphine are equally potent as analgesics [ 33 ] . However, other reports have described nalbuphine as a "mixed agonist/antagonist" with agonism at κ opioid receptors and antagonism at μ opioid receptors based on in vivo data [ 11 33 ] . This categorization is likely due to the fact that nalbuphine has been shown to reduce the ventilatory depressant effect of other opioids, while adding to their analgesic effect [ 33 ] . Nalbuphine is also used clinically to reduce the opioid-mediated side effects such as itching, without completely reversing the analgesic effects of the full agonists [ 34 35 36 ] . According to our data, although nalbuphine is clearly a potent agonist at μ receptors, its levels of agonism is significantly lower than the very efficacious drug fentanyl and the endogenous ligand β-endorphin.

  • Pharmacological tolerance to analgesics (ie, the reduced effectiveness of a given dose of medication over time), is not evidence of addiction, [ 30 ] and is rarely significant clinically.


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