Example sentences for: alterations

How can you use “alterations” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Thus, hERα provides a useful prognostic index in patients with metastatic disease and is associated with disease-free survival [ 7 8 9 10 ] . However, 35% of all patients with hERα positive (ER+) tumors do not respond to hormonal interventions suggesting cellular and molecular alterations [ 6 11 12 ] .

  • Although alterations in mitochondrial morphology do not necessarily reflect well-defined mitochondrial disorders and we cannot completely exclude the possibility of an unknown metabolic disorder with secondary mitochondrial dysfunction, we speculate that all the clinical, biochemical and histological features in the proband can be attributed to disturbed mitochondrial energy metabolism.

  • The heterogeneous nature of breast cancer alterations could have important implications for the development of targeted therapies.

  • Gene models were checked to ensure that they did not overlap transposable elements and that they did not have major alterations of their intron-exon structure due to the presence of unmasked data.

  • We are not yet at a stage in our understanding of breast disease such that genetic alterations can substitute for the histopathology of the lesion.


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