Words similar to alterations

Example sentences for: alterations

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In addition, the increase in K i was identical to the increase in K d that has been observed for [ 3H]granisetron binding on this mutant [ 24 ] . Alterations in K i resulting from the W89Y mutation were slightly less, however the change was again the same for lerisetron, analog 1 and analog 2. These data suggest that all three compounds form binding site interactions with W89.
The heterogeneous nature of breast cancer alterations could have important implications for the development of targeted therapies.
Some of these variants have been independently observed by other groups: NF1ins4a-2 [ 14 15 16 ] , NF1ΔE4b [ 14 15 16 ] , NF1ΔE7 [ 15 19 ] , NF1ΔE29/E30 [ 11 ] , NF1ΔE30 [ 11 ] , NF1ΔE33 [ 16 ] , NF1ΔE34 [ 16 ] , NF1ΔE37 [ 15 16 ] , NF1ΔE43 [ 16 ] , NF1-Δ7605-7675 [ 16 ] and NF1ΔE45 [ 16 ] . Some of these transcripts increased with time or cold shock [ 14 16 ] . It has been shown that ~30 % of NF1 germline mutations result in splicing errors [ 13 20 ] . The vast majority of them are due to alterations outside the canonical AG/GT acceptor and donor splice sites.
Ciliates employ a strategy of irreversible genome alterations to generate the MAC, a specialized gene-expression organelle.
Beyond SRY , there are several autosomal genes including the SRY -related SOX9 gene [ 9, 10], MIS [ 11, 12], SF1 [ 13], WT1 [ 14] and DMRT1 [ 15] that contribute to sexual organ formation, alterations of which can cause male-to-female sex reversal in XY males.