Example sentences for: alterations

How can you use “alterations” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In the presence of alterations in the blood-brain barrier, injection of contrast material increases brain oedema [ 6, 7, 8, 9].

  • In humans, our group and one other have demonstrated marked alterations in MHC expression in the diaphragm in severe emphysema [ 12 13 ] . This shift toward slow MHC isoforms has been proposed to subserve an adaptive resistance to fatigue in the human diaphragm in emphysema which is similar to that seen in the animal model.

  • Therefore, it is possible that alterations in the activities of integrins or adhesive sites on other ECM molecules induced by the whole cCAF molecule, and not by the N-peptide, could affect FN accumulation [ 47 ] . We are currently pursuing studies to determine whether adhesion molecules or other ECM molecules play a role in FN accumulation due to cCAF-induced TN production.

  • It is unlikely that these alterations in alphaA/BKO mouse lenses result from increased susceptibility of these lenses to light-induced damage in the absence of the molecular chaperone protection afforded by alphaA and alphaB in normal lenses.

  • The expression of genes encoding α-tubulin and β-tubulin seems to be developmentally regulated [ 19 ] . For example, tubulin isotype expression patterns change during the development and maturation of neurons [ 14 20 ] . Studies with paclitaxel or other antimitotic agents, such as colchicine or estramustine, indicate that drug interactions with tubulin isotypes differ [ 21 22 23 24 25 ] and might contribute to cell resistance to antimitotics [ 26 27 28 29 30 31 ] . However, one group of antimitotic agents, the vinca alkaloids, was shown to bind with similar affinity to all tubulin isotypes [ 12 ] , suggesting that alterations in drug binding affinity is unlikely to be the cause of drug resistance.


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