Example sentences for: alteration

How can you use “alteration” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • COX-2 is an inducible enzyme upregulated in inflammatory states [ 20 21 ] . Notably, many NSCLC and what have been characterized as "premalignant" lung lesions have been shown to constitutively express the COX-2 enzyme and produce prostaglandin E-2 (PGE-2), the primary product of the COX-2 pathway [ 22 23 24 25 26 ] . Importantly, PGE-2 production by tumor cells has been linked to tumor-induced immunosuppression in NSCLC [ 2 3 4 5 ] . PGE-2 has been shown to directly suppress T cell mediated immunity, the primary effector against tumor cells, at a variety of levels [ 2 3 4 5 6 7 ] . Further, PGE-2 has been shown to induce the IL10 in mononuclear cells [ 4 5 ] . IL10 is a prominent immunosuppressive cytokine that may have a dominant role in preventing innate antitumor responses in the NSCLC environment [ 2 3 4 5 ] , [ 8 9 10 11 12 13 14 15 16 17 18 19 ] . Among myriad suppressive effects on T cells and antigen presenting cells, IL10 is known to inhibit IL12 production [ 14 15 16 17 18 ] . IL12 plays a key role in the initiation and potentiation of cellular immune responses and alteration of the IL12 producing function in circulating mononuclear phagocytes may be a critical factor in suppressed T cell immunity to NSCLC [ 27 28 ] .

  • Thus an alteration in the PG E 2 /F 2α ratio plays an important role in mediating IDO's effects on cell growth and morphology.

  • The alteration of tsk to tisk is like the back-formation of certain words.

  • that antioxidant enzyme activity in the liver was altered following long term consumption of n-3 PUFAs [ 14 ] . We reasoned that alteration of antioxidant enzyme activity in the tumor by consumption of n-3 PUFAs prior to chemotherapy treatment could increase oxidative stress within the tumor, perhaps resulting an enhanced sensitivity to oxidative stress induced by doxorubicin (DOX).

  • Transient improvement in oxygenation may have occurred because of increased minute ventilation secondary to alteration in tidal breathing pattern following aerosol administration without bronchodi-lation.


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