Example sentences for: alteration

How can you use “alteration” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Indeed, the alteration in C. trachomatis of many otherwise invariant amino-acid residues is evident from the information given in Table 2.

  • For instance, IL-1-degraded cartilage tissues and cell suspensions are frequently employed as model systems to study cartilage metabolism under osteoarthritis-like conditions [ 1 2 3 4 ] and to assess the efficacy of various drug therapies [ 5 6 7 8 9 ] . IL-1 signals cells via cell surface receptors to upregulate proteases, matrix metalloproteinases and aggrecanase, while downregulating matrix metalloproteinase inhibition and proteoglycan synthesis [ 10 11 ] . The ultimate effect of these metabolic changes include damage to the ECM, loss of ECM components (especially proteoglycan), and alteration of the normal balance of catabolic and anabolic processes that regulate cartilage ECM composition.

  • The mutant gene encodes β-catenin protein stabilized by alteration of a phosphorylation site required for proteosomal degradation.

  • The CBF response curve to acetazolamide can be considered like a high pass filter with an onset time constant to a steady state τ 1 and an offset time constant of τ 2 . Alteration and prolongation of τ 2 will correspond to prolonged cerebral vascular response time . An important concept of a high pass filter is that the system response is dependent on both the resistive (R) and capacitative (C) elements.

  • Evaluation of results from derivative control oligonucleotides showed that long oligonucleotides could tolerate 10% mismatches; however, alteration of the target sequence by more then 20% eliminated most of the hybridization signal.


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