Words similar to als

Example sentences for: als

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- ALS : Anterolateral system
Interestingly, accumulation of ceramides and cholesterol esters has been observed in ALS patients and mice [ 67 ] , which could be associated with peroxisomal proliferation.
We also used the monoclonal antibody α-ALS (mab D4) and a polyclonal serum α-Dα2, both directed against α-like ligand-binding subunits of the Drosophila nAChR [ 25, 28].
[ 28] Initial screening of α-ALS and α-Dα2 sera showed no cross-reactivity in western blots when Drosophila and Calliphora brain homogenates were compared (data not shown).
Mutant SOD1 causes dysfunction and structural damage of mitochondria in cultured neuronal cells [ 18 19 20 ] and at early disease stages in mutant SOD1 transgenic mice [ 21 22 ] . Human ALS also shows mitochondrial damage, dysfunction and loss [ 23 24 ] . The mechanism whereby mutant SOD1 causes mitochondrial damage has not been determined, but recent evidence shows that mutant SOD1 is imported into mitochondria [ 21 25 26 ] , and this mitochondrial localization may cause direct damage to mitochondria and induce cell death [ 27 ] . Consistent with this possibility, previous work suggested that mitochondrial vacuolation was developed from expansion of the intermembrane space [ 17 ] . However, the possibility that the vacuoles represent autophagic vacuolation has not been ruled out, because the source of the vacuolar membrane was not known.