Words similar to alanyl
Example sentences for: alanyl
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The aim of this study was therefore to determine whether elevated antibody responders to D-alanyl LTA show a association of DMFT with fluoride exposure and gingival health not apparent in low responders.
Streptococcus mutans in which DCP is inactive do not initiate growth at below pH 6.5 and make glycerol LTA without D-alanine [ 14 ] . In the DCP active strains, soluble D-Alanyl LTA is extruded into culture fluid in vitro [ 16 17 ] or plaque in vivo [ 18 ] . The D-alanyl esters are stable at pH 6.0 at 37°C, but hydrolyze to free D-alanine and LTA with a half-life of 3.9 h at pH 8.0 [ 19 ] . Healthy gingival sulci have a pH of 6.5 - 7.5 and inflamed sulci a pH of 7.5-8.
About 30% of young adults have serum IgG antibodies that precipitate with D-alanyl LTA, but not with D-alanine-free LTA [ 17 21 ] . It is likely that plaques induce these IgG antibodies from gingival sulci that contain more acid-tolerant bacteria.
D-alanyl LTA, but not D-alanine-free LTA, is present in culture filtrates of Streptococcus mutans GS5 [ 17 ] . Bacteria were grown at 37°C in trypticase soy broth to late stationary phase (96 h), when the maximal amount of antigen is extruded into the culture fluid [ 18 ] . After centrifugation to remove the bacteria, culture fluid (10 1) was concentrated 20-fold over a YM10 Diaflo Membrane filter (Amicon Corp., Beverley, MA).
Although this study has indicated that the IgG antibodies to D-alanyl LTA do not become elevated until after age 17, when much caries may have already developed, they may be elevated to a lower level in children who eventually become high responders.
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