Example sentences for: alanines

How can you use “alanines” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To test this hypothesis, we mutated the opossum alpha-2C serines and threonine residues to alanines and valine, respectively, and tested whether the expressed receptors would down-regulate.

  • Sequentially mutating each of the four serines to alanine decreased the phosphorylation of the receptor by approximately 25% for each serine, and mutating either the first two or the last two serines to alanines prevented agonist-induced desensitization, but not agonist-induced sequestration/internalization [ 12 ] . The influence of mutations in this motif on down-regulation has not been investigated.

  • Substitution of the three threonines with alanines produces the 3 × Ala mutant that behaves like a constitutively unphosphorylated myosin-II.

  • A recent study identified a number of α5 helix residues in α t that when changed to alanines increased rates of guanine-nucleotide exchange ( i.e., decreased affinity for guanine-nucleotides) [ 5 ] . Individual mutation of amino acids in α t , cognate to T330, N332, V333, F337 in α i2 (Figure 1), increased nucleotide exchange rates [ 5 ] . Two of these critical amino acids, N332 and V333 in α i2 , are in fact the first two amino acids that are replaced by the novel splicing in sα i2 (Figure 1).

  • Interestingly, in the other study, the authors found that deletion of a proline-rich sequence corresponding to sα i2 amino acids 348-359 (Figure 1) changed localization of sα i2 from Golgi membranes to a more diffuse localization throughout intracellular membranes [ 4 ] . However, mutation of proline residues to alanines failed to affect sα i2 localization [ 4 ] . Thus, little evidence exists to support a specific membrane targeting role for the novel sα i2 sequence.


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