Words similar to affinity
Example sentences for: affinity
How can you use “affinity” in a sentence? Here are some example sentences to help you improve your vocabulary:
Recombinant V80R and A61D mutants were expressed in E. Coli BL21 (DE3) pLysS cells (Novagen), and purified by Ni-NTA (Qiagen) and HiTrap SP (Pharmacia) affinity column chromatography followed by ammonium sulfate precipitation as described by Kim et al [ 7 ] .
The amino acid sequence of the heparin-binding region of HB-EGF ( 21KRKKKGKGLGKKRDPCLRKYK 41) [ 2 ] has been shown to have a strong affinity for heparin and may influence the interaction of this growth factor with cell-surface negatively charged heparan sulfate proteoglycans [ 22 ] . It remains to be seen whether specific/all of the EGF-like modules are required and whether calcium is needed for the interaction of HB-EGF with LTBP-3.
A positive change thus corresponds to a decrease in binding affinity for the compound as a result of the mutation.
The inability of the S22N substitution to substantially reduce the affinity of Rab24 for GTP adds to the growing list of fundamental differences between Rab24 and other members of the Rab family.
The expression of genes encoding α-tubulin and β-tubulin seems to be developmentally regulated [ 19 ] . For example, tubulin isotype expression patterns change during the development and maturation of neurons [ 14 20 ] . Studies with paclitaxel or other antimitotic agents, such as colchicine or estramustine, indicate that drug interactions with tubulin isotypes differ [ 21 22 23 24 25 ] and might contribute to cell resistance to antimitotics [ 26 27 28 29 30 31 ] . However, one group of antimitotic agents, the vinca alkaloids, was shown to bind with similar affinity to all tubulin isotypes [ 12 ] , suggesting that alterations in drug binding affinity is unlikely to be the cause of drug resistance.
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