Words similar to affinities
Example sentences for: affinities
How can you use “affinities” in a sentence? Here are some example sentences to help you improve your vocabulary:
haloperidol) because of their lower incidence of extrapyramidal side effects, their greater efficacy in improving negative symptoms of schizophrenia, and their effectiveness in treating schizophrenic patients not responding to conventional neuroleptics [ 3 ] . However, side effects continue to pose a challenge to effective treatment [ 4 ] . These novel neuroleptics display a complex pharmacological profile with affinities for several receptor systems but are generally characterized by a greater affinity for the 5-HT2A receptor than for the target of the traditional neuroleptics, the D2 receptor [ 4 5 ] .
To explore the evolutionary affinities of the ERF domains, we carried out a sequence profile analysis as described above for the RecT case using transitive PSI-BLAST analysis.
The RDRPs of RNA viruses define one major lineage of nucleic acid polymerases, which additionally includes reverse transcriptases, archaeo-eukaryotic DNA polymerases, and nucleotide cyclases [ 8 9 10 11 12 13 ] . The DNA-dependent RNA polymerase of certain bacteriophages, such as T7, and the archaeo-eukaryotic primase (also detected in some bacteria) are divergent derivatives of the same fold [ 11 14 ] . The core catalytic domain of all these enzymes, the so-called "palm" domain, has an RNA-recognition motif (RRM)-like fold with strategically placed metal-coordinating residues, which form the active site [ 11 15 16 ] . In contrast, bacterial DnaG-type primases (also present in archaea and some eukaryotes) contain a polymerase domain of the Rossmann-like TOPRIM fold, which is shared with topoisomerases and OLD-family nucleases [ 17 18 19 ] . The recently solved structures of the DDRPs from yeast and the thermophilic bacterium Thermus thermophilus indicate that the β' subunit (according to the subunit nomenclature of Escherichia coli DDRP, which we hereinafter employ to designate all orthologs of the respective E. coli subunits) of these enzymes defines another distinct catalytic scaffold, which is unrelated to any of the above template-dependent RNA polymerases [ 20 21 22 23 24 ] . Additionally, the structural and evolutionary affinities of two other template-dependent RNA polymerases, namely RDRPs involved in PTGS [ 25 26 27 ] and primases of herpesviruses [ 28 ] , remain obscure.
Thus, profiling the BMP binding affinities as well as the expression patterns of these BMP antagonists will be critical to understanding the regulation of BMP-5 signaling in the nervous system.
Binding studies indicated that the affinity of the cadherin for Cry1Aa is equivalent to that of the brush border membrane vesicles from B. mori [ 16 ] , an affinity that is substantially lower than the APN affinities reported.
Loading...