Words similar to affinities
Example sentences for: affinities
How can you use “affinities” in a sentence? Here are some example sentences to help you improve your vocabulary:
While both these ligands bind with high affinities (less than 1 nM) to μ opioid receptors, WIN 44,441 acts as an antagonist at μ opioid receptors and xorphanol is a very weak agonist at μ opioid receptor (Gharagozlou et al.
Finally, possible side effects of neuroleptics, such as urinary retention, may be predicted from binding studies using human brain tissue [ 12 ] if antimuscarinic affinities will correspond to antimuscarinic effects on the bladder.
In cats, serotonin antagonists caused a decrease in bladder capacity [ 43 ] however in anesthetized rats, serotonin antagonism did not have an effect on micturition [ 44 ] . Recently, a selective 5-HT1A receptor antagonist (WAY-100635) was reported to inhibit bladder contractions in rats [ 45 ] yet another report only observed an increase in the pressure threshold [ 46 ] . Olanzapine and risperidone have only low to modest affinity for the 5-HT1A receptor, and higher affinities for the 5-HT2A and 5-HT2C receptors [ 11 12 ] . Serotonin 5-HT2 and 5-HT3 receptors facilitate pudendal reflexes in the cat [ 47 48 ] , therefore it is possible that antagonism of these receptors may block the EUS in the anesthetized rat.
(Stoppard, born Tomas Straussler in Czechoslovakia in 1937, has also shown some affinities with the playful philosophical playwrights of his native country, from Carel Capek in the 1920s to Pavel Kohout and Václav Havel in the '60s and '70s.)
Thus, profiling the BMP binding affinities as well as the expression patterns of these BMP antagonists will be critical to understanding the regulation of BMP-5 signaling in the nervous system.
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