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Example sentences for: af-
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A number of RXR heterodimer complexes have been categorized as either permissive or non-permissive based on their responses to RXR ligands [ 1 ] . Although there are some reported discrepancies, the PPAR, FXR and NGF-IB/NURR1 complexes are generally considered permissive, while the non-permissive group includes the RAR, TR and VDR complexes (see [ 2 3 4 5 6 7 ] ). In the permissive complexes, coactivators can presumably bind to the AF-2 surface of both partners and binding to the RXR partner is stimulated by rexinoid agonists.
In other cases, however, the balance of coactivator and corepressor recruitment is regulated by direct competition for the AF-2 surface, rather than ligand-dependent coregulator exchange.
Thus, ERβ interactions with N-CoR are dependent on the AF-2 surface (including H12) and, in this regard, resemble those of ERβ and GRIP1.
Moreover, other mutations in the upper part of the H3-H5 region that comprises the AF-2 surface (D303Y, I310R and K314A on H3; V328R and L331R on H5) abolished ERβ interaction with both cofactors.
This sequence does not exactly conform to the LXXLL consensus, but contains features (underlined) that resemble the ERβ H12 region (L L LE ML ), and artificial ERβ interacting LXXLL peptides (293, P NLIS LLS ; D47, PL LLS LLS ), both of which bind to the ERβ AF-2 surface [ 43 44 45 46 47 ] . Moreover, the presence of a proline residue amino-terminal to the hydrophobic groups is typical of so-called class II LXXLL motifs which are found in ERβ interacting cofactors such as TRAP220 and RIP140 [ 45 ] . Finally, the unusual C-terminal hydrophobic pair (ML) has been observed in ERα and ERβ H12 [ 43 44 48 ] , and in RIP140 NR boxes [ 19 ] .
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