Words similar to admixture
Example sentences for: admixture
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Modification of the ancestral chromosome by recombination and admixture as a result of geographic migration could explain the previously undescribed occurrence of HLA haplotypes that occur in association with C282Y.
One of the causes for conflicting results in candidate gene studies and in particular for spurious associations is believed to be population stratification or admixture [ 25 ] . Population stratification refers to the presence of subgroups, e.g. ethnic groups, in the sample and can potentially cause a spurious association between the locus and trait.
This disorder is typically associated with homozygosity for the C282Y mutation of the HFE gene (exon 2, nt 845 G→A) on Ch6p [ 1 ] . C282Y lies within an ancestral haplotype which includes the human leukocyte antigen (HLA) haplotype A*03-B*07 [ 2 3 4 5 ] . The ancestral haplotype is the predominant hemochromatosis-associated haplotype in many northwestern European countries, including Ireland [ 6 ] , Brittany [ 2 ] , Denmark [ 7 8 ] , Sweden [ 9 ] , and Germany [ 10 11 ] . This is attributed to the origin of the C282Y mutation on an A*03-B*07 haplotype in northwestern Europe and its early dissemination by Vikings [ 3 12 ] . Modification of the ancestral chromosome by recombination and admixture as a result of geographic migration explains the occurrence of chromosomes bearing C282Y in association with different HLA haplotypes [ 2 4 8 13 14 15 16 ] . Thus some non-ancestral haplotypes also occur with significantly increased frequencies in hemochromatosis patients in various countries in Europe and in descendants of Europeans [ 5 16 ] .
It is possible that modern humans exhibit some form of hybrid vigor simply because migration and admixture of populations are now occurring at unprecedented rates.
In fact, distinct and dispersed subsets of proteins having the same substrate specificity may exist within a single protein family whose members possess an admixture of different substrate specificities.
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