Example sentences for: admixture

How can you use “admixture” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This disorder is typically associated with homozygosity for the C282Y mutation of the HFE gene (exon 2, nt 845 G→A) on Ch6p [ 1 ] . C282Y lies within an ancestral haplotype which includes the human leukocyte antigen (HLA) haplotype A*03-B*07 [ 2 3 4 5 ] . The ancestral haplotype is the predominant hemochromatosis-associated haplotype in many northwestern European countries, including Ireland [ 6 ] , Brittany [ 2 ] , Denmark [ 7 8 ] , Sweden [ 9 ] , and Germany [ 10 11 ] . This is attributed to the origin of the C282Y mutation on an A*03-B*07 haplotype in northwestern Europe and its early dissemination by Vikings [ 3 12 ] . Modification of the ancestral chromosome by recombination and admixture as a result of geographic migration explains the occurrence of chromosomes bearing C282Y in association with different HLA haplotypes [ 2 4 8 13 14 15 16 ] . Thus some non-ancestral haplotypes also occur with significantly increased frequencies in hemochromatosis patients in various countries in Europe and in descendants of Europeans [ 5 16 ] .

  • One of the causes for conflicting results in candidate gene studies and in particular for spurious associations is believed to be population stratification or admixture [ 25 ] . Population stratification refers to the presence of subgroups, e.g. ethnic groups, in the sample and can potentially cause a spurious association between the locus and trait.

  • Modification of the ancestral chromosome by recombination and admixture as a result of geographic migration could explain the previously undescribed occurrence of HLA haplotypes that occur in association with C282Y.

  • It is possible that modern humans exhibit some form of hybrid vigor simply because migration and admixture of populations are now occurring at unprecedented rates.

  • In fact, distinct and dispersed subsets of proteins having the same substrate specificity may exist within a single protein family whose members possess an admixture of different substrate specificities.


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