Words similar to admixture
Example sentences for: admixture
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Modification of the ancestral chromosome by recombination and admixture as a result of geographic migration could explain the previously undescribed occurrence of HLA haplotypes that occur in association with C282Y.
This disorder is typically associated with homozygosity for the C282Y mutation of the HFE gene (exon 2, nt 845 G→A) on Ch6p [ 1 ] . C282Y lies within an ancestral haplotype which includes the human leukocyte antigen (HLA) haplotype A*03-B*07 [ 2 3 4 5 ] . The ancestral haplotype is the predominant hemochromatosis-associated haplotype in many northwestern European countries, including Ireland [ 6 ] , Brittany [ 2 ] , Denmark [ 7 8 ] , Sweden [ 9 ] , and Germany [ 10 11 ] . This is attributed to the origin of the C282Y mutation on an A*03-B*07 haplotype in northwestern Europe and its early dissemination by Vikings [ 3 12 ] . Modification of the ancestral chromosome by recombination and admixture as a result of geographic migration explains the occurrence of chromosomes bearing C282Y in association with different HLA haplotypes [ 2 4 8 13 14 15 16 ] . Thus some non-ancestral haplotypes also occur with significantly increased frequencies in hemochromatosis patients in various countries in Europe and in descendants of Europeans [ 5 16 ] .
Standard formulae were used to calculate cardiac index (CI), PVRI, systemic vascular resistance index (SVRI), right ventricular stroke work index (RVSWI), venous admixture (Q VA /Q T ), arteriovenous oxygen difference [C(av)O 2 ], oxygen delivery (DO 2 ), oxygen extraction ratio (EaO 2 ) and oxygen consumption (VO 2 ).
Furthermore, the study of other genetic markers, namely the distribution of β-globin haplotypes and the frequency of deletional α-thalassemia among African-American patients with sickle cell disease from different centers in the United States do not show significant differences arguing against significant population admixture in this group [ 4 11 30 31 ] .
Two-point linkage in the presence of locus heterogeneity was assessed by the admixture test of Ott, using HOMOG [ 36 ] . We used a heterogeneity LOD (HLOD) of > 1.3 to indicate nominal evidence for linkage for all linkage analyses [ 37 ] .
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