Words similar to adaptor
Example sentences for: adaptor
How can you use “adaptor” in a sentence? Here are some example sentences to help you improve your vocabulary:
The cell surface expressed integrins can control this process by physically interacting with the extracellular matrix proteins and other cell surface proteins on endothelial cells lining the blood vessel wall [ 1 ] . These integrins signal adhesion and migration by communicating with several tyrosine kinases inside the cell, including the Focal Adhesion Kinase (FAK) and Src family kinases [ 1 2 ] . Src kinases control the activation of FAK, as well as the tyrosine phosphorylation of critical substrates that regulate adhesion and migration [ 3 ] . Indeed, colon cancer cells with high metastatic potential have elevated levels of Src activity or activating mutations in the Src gene [ 4 5 ] . One Src substrate that is involved in regulating an important signaling node in this process is the adaptor protein p130 cas (Cas) [ 6 7 8 9 10 ] . Cas appears to play a central role in the transformation process by several oncogenes including ras, ornithine decarboxylase (ODC), v-Src, v-crk, and Bcr-Abl, as these tumors all have elevated levels of tyrosine phosphorylated Cas [ 6 11 12 13 ] . Cells from mice that lack Cas have much reduced migration and are resistant to transformation by v-Src, while expression of Cas anti-sense RNA in cells transformed with ras, v-Src or ODC result in reversion of the transformed phenotype [ 11 14 15 ] . Furthermore, increased expression of Cas can rescue cell migration and adhesion in cells expressing the tumor suppressor PTEN, and can enhance cell migration and adhesion in normal cells, with a major role being played by the substrate domain [ 16 17 ] .
While these upstream kinases lead to tyrosine phosphorylation of the adaptor and activation of downstream effectors, they usually also activate other signaling pathways that can confound analysis of the specific role of the tyrosine phosphorylated adaptor protein.
This user interface is the other class (in addition to the DataAdapter itself) that the software developer must provide to add an external adaptor.
Their group wrote a custom data adaptor to load their data that uses either chromosome and range, or a sequence, or a sequence name to query their internal data source and then display the specified region in Apollo.
Briefly, synthesized cDNA was digested with the restriction enzyme Rsa1 and the tester cDNA populations were divided into two tubes and ligated to both adaptor 1 or adaptor 2R.
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