Example sentences for: acyclovir

How can you use “acyclovir” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • However, it appeared that therapies such as oral administration of certain NMDA receptor antagonists, codeine, ibuprofen, lorazepam, 5HT1 receptor agonists, and acyclovir were not efficacious in PHN.

  • Thymidine kinase polypeptide (TK) is required for the activation of some antiviral nucleoside analogs e.g. acyclovir (ACV) and penciclovir (PCV), in order to inhibit viral DNA replication.

  • [ 31 ] Acyclovir 250 mg/m 2per day IV or 400-800 mg PO bid, allopurinol 300 mg PO qd and fluconazole 400 mg PO qd were administered prophylactically.

  • Resistance to acyclovir (ACV) or penciclovir (PCV) generally arises by a single base mutation in either the HSV thymidine kinase (TK) or DNA polymerase (Pol) gene [for a review, see reference [ 5 ] ]. Unlike Pol, TK is not essential for virus replication in cell culture [ 7 ] , although in vivo analyses implicate it in HSV virulence, pathogenicity and reactivation from latency [ 4 8 16 22 ] . Since ACV and PCV are dependent upon HSV TK for monophosphorylation, an event obligatory for the formation of the active triphosphate inhibitor [ 14 ] , ACV risolates often exhibit high levels of cross-resistance to PCV [ 2 3 ] .

  • Acyclovir has been in part superceded by the oral prodrugs valaciclovir (VCV) and famciclovir (FCV), the latter being the oral version of PCV [ 20 24 ] . No comparative studies of the emergence of resistance following sub-optimal VCV or FCV have been reported and therefore set out to to select for HSV-1 and HSV-2 isolates resistant to ACV and PCV after using prodrug selection.

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