Example sentences for: acute-phase

How can you use “acute-phase” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Tumor necrosis factor (TNF) has been implicated in the development and pathogenicity of infectious diseases and autoimmune disorders, such as septic shock, arthritis, and hypotension [ 1 2 3 4 ] . It plays a pivotal role in the inflammatory cascade and, together with IL-1 and IL-6, has been shown to mediate the acute-phase response [ 5 6 ] . Confirmation of its significance in disease comes from the success of clinical trials using anti-TNF therapy to treat rheumatoid arthritis and Crohn's disease [ 7 8 9 10 ] .

  • The inability of rhIL-11 to bring about a statistically significant improvement in the ACR 20% criteria may also be the result of an inability of rhIL-11 to stimulate the synthesis of acute-phase proteins, of the significant clinical response of several placebo-treated patients, or of a lack of adequate power of the study to show efficacy.

  • SPI-3 has been shown to be a downstream target of both the inflammatory acute-phase regulators TNFα and IL-6 [ 33 ] . Positive correlation with an intermediate conductance calcium-activated potassium channel SMIK (AF190458) was common to the metrics related to vacuole density, area % vacuoles and vacuoles/mm 2. CCl 4 treatment perturbs the balance of many serum electrolytes [ 34 ] , and an increase in the SMIK channel might help re-establish normal potassium homeostasis as the liver recovers from the toxic stress.


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