Example sentences for: actin

How can you use “actin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To sum up, profilin can act as a major liaison between viral proteins and actin, and articulate multiple outcomes for both the cell and the virus, involving signal transduction as well as cytoskeletal changes (Fig.

  • Many branched microextensions were double-stained with these antibodies, but occasionally, part of a microextension or an entire microextension apparently lacked actin [ 17, 22].

  • Latrunculin B depolymerizes actin microfilaments and hence should release components that normally associate with the actin cytoskeleton.

  • E174 in ACR3 and S218 in ACR4 are required for catalytic function [ 12 ] . Substitution of H59 in ACR1 converted CD39 into an ADPase in a quaternary structure dependent manner [ 13 ] . Mutation of W187A in ACR3 affected CD39 folding and translocation, while mutation of W459A in ACR5 increased ATPase activity but diminished ADPase activity [ 14 ] . Mutations of D62 and G64 of ACR1 and D219 and G221 of ACR4 demonstrated that the nucleotide phosphate binding domains of NTPDases are similar to those present in the actin/heat shock protein/sugar kinase superfamily [ 15 ] . These results suggest that the conserved residues of the ACR1 to 5 regions are involved in the catalytic mechanism of CD39.

  • Biochemical reconstitution studies using purified recombinant actin in vitro and studies in RSV-infected cells ( ex vivo ) demonstrated that actin functions as a viral transcription factor in both monomeric (G) and filamentous (F) forms, whereas the filamentous form appeared to be particularly important for viral morphogenesis [ 10 ] . Subsequent studies showed that at saturating actin concentration, profilin stimulated viral transcription even further, whereas profilin by itself had no transcriptional activity in the absence of actin [ 11 ] . These results suggested that the interaction of profilin with actin may be important for optimal activity of the RSV transcriptase.


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