Example sentences for: acta

How can you use “acta” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Detailed comparisons of the response to wild-type and actA mutant infections were designed to uncover gene-expression programs specific to the motility phase of the infection, when bacterially directed actin polymerization is induced to move the bacteria through the cytoplasm.

  • Three strains of L. monocytogenes were used; wild type (10403S), a mutant for the transcriptional regulation of virulence genes, prfA (DP-L1075) [ 33], and a mutant deficient for intracellular motility, actA (DP-L1942) [ 30].

  • By the same sets of criteria described above for studying the difference between wild-type and actA infections, we examined whether there were any genes reproducibly induced by cytoplasmic bacteria (wild-type or actA ) but not by the avirulent organism ( prfA ). In this dataset, no genes passed these criteria during the first 4 hours of infection.

  • It is likely that differences in the transcriptional program would emerge at later stages of infection, as wild-type and actA bacteria replicate and kill the cells, and prfA do not.

  • To this end, we carried out similar 8-hour time courses with an isogenic L. monocytogenes strain deficient in actA (DP-L1942, Δ actA ), which is unable to nucleate actin polymerization and hence has no capacity for intracellular motility and intercellular spread [ 30].


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