Example sentences for: abl

How can you use “abl” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The proto-oncogene TEL (Translocation, Ets, Leukemia) is a transcriptional repressor that contains a C-terminal Ets family DNA binding domain; a central domain that together with co-repressors recruit histone deacetylases [ 1 2 3 ] ; and an N-terminal SAM (sterile, alpha, motif) domain [ 4 5 6 ] , which we have recently shown forms a polymer [ 7 ] . Chromosomal translocations in a variety of leukemias result in fusion of the SAM domain of TEL to tyrosine kinase domains such as ABL, PDGFβ and JAK2 [ 8 9 10 11 12 13 14 ] or to the transcriptional activators AML1 and ARNT [ 15 16 17 ] . In the tyrosine kinase fusions, SAM domain polymerization leads to constitutive activation of the tyrosine kinase domains, which leads in turn to cell transformation [ 10 12 18 19 ] . Thus, compounds that block TEL-SAM polymerization could be effective in treating these leukemias.

  • Interestingly, three genes whose products are known to promote viral replication were associated with v- myb and v- abl oncogenes (shared terms: 'virus', 'transformation' or 'leukemia'): TAX1BP1 (Tax1-binding protein 1), CREB3 (cAMP-response element binding protein 3/LZIP) and TARBP2 (TAR-binding protein 2) (Figure 7a) [ 20, 21, 22].

  • The Rlk fusion proteins also failed to efficiently bind SH3 domains from other kinases, including Abl, Csk and Btk.

  • These target proteins include the c-Abl tyrosine kinase, the p53 tumor suppressor, the Chk1 and Chk2 serine/threoine kinase, the p34 subunit of replication protein A (RPA), Chk1 serine/threoine kinase and NBS1 kinase which is mutated in human autosomal recessive disease Nijmegan breakage syndrome [ 16 17 18 19 20 21 22 23 ] . Clinical characteristics of AT patients include hypersensitivity to irradiation, thymic dysplasia, immune defects and higher tendency to develop malignant tumor, suggesting that ATM function is critical in DNA damage repair and tumor suppression.

  • This fact is reflected in the analysis of literature profiles, as groups of genes could be found to be associated with brain tissues (Figure 7f, for example, HPCA (hippocalcin), SYP (synaptophysin), GRIK1 (glutamate receptor, ionotropic, kainate 1), APLP (amyloid beta A4 precursor-like protein)), immune cells (Figure 7b, for example, CD40, IL15RA (IL-15 receptor, alpha chain), LILB4 (leukocyte immunoglobulin-like receptor 4)) or tumor cells (Figure 7a, for example, MYBL1 (v- myb avian myeloblastosis viral oncogene), ABL2 (v- abl Abelson murine leukemia viral oncogene homolog 2)).


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