Example sentences for: abl

How can you use “abl” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Crystallographic studies of various ABL mutants predict that most should remain sensitive to inhibitors that bind ABL with less stringent structural requirements.

  • Imatinib (Gleevec), a 2-phenylaminopyrimidine, is a competitive inhibitor of ATP binding to the ABL kinase, thereby inhibiting the constitutively activated BCR-ABL tyrosine kinase.

  • In contrast to the spatially restricted functions of CAP, Ena, and Abl, profilin and cofilin were shown to regulate actin filament formation throughout the cell cortex, a more global function that matches the results obtained in cell culture experiments.

  • This fact is reflected in the analysis of literature profiles, as groups of genes could be found to be associated with brain tissues (Figure 7f, for example, HPCA (hippocalcin), SYP (synaptophysin), GRIK1 (glutamate receptor, ionotropic, kainate 1), APLP (amyloid beta A4 precursor-like protein)), immune cells (Figure 7b, for example, CD40, IL15RA (IL-15 receptor, alpha chain), LILB4 (leukocyte immunoglobulin-like receptor 4)) or tumor cells (Figure 7a, for example, MYBL1 (v- myb avian myeloblastosis viral oncogene), ABL2 (v- abl Abelson murine leukemia viral oncogene homolog 2)).

  • For example, in CML, a commonly found mutation is a C→T single nucleotide change that replaces threonine with isoleucine at position 315 (T315I) in the ABL kinase domain [9,10,11].


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