Example sentences for: abl

How can you use “abl” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Interestingly, three genes whose products are known to promote viral replication were associated with v- myb and v- abl oncogenes (shared terms: 'virus', 'transformation' or 'leukemia'): TAX1BP1 (Tax1-binding protein 1), CREB3 (cAMP-response element binding protein 3/LZIP) and TARBP2 (TAR-binding protein 2) (Figure 7a) [ 20, 21, 22].

  • The proto-oncogene TEL (Translocation, Ets, Leukemia) is a transcriptional repressor that contains a C-terminal Ets family DNA binding domain; a central domain that together with co-repressors recruit histone deacetylases [ 1 2 3 ] ; and an N-terminal SAM (sterile, alpha, motif) domain [ 4 5 6 ] , which we have recently shown forms a polymer [ 7 ] . Chromosomal translocations in a variety of leukemias result in fusion of the SAM domain of TEL to tyrosine kinase domains such as ABL, PDGFβ and JAK2 [ 8 9 10 11 12 13 14 ] or to the transcriptional activators AML1 and ARNT [ 15 16 17 ] . In the tyrosine kinase fusions, SAM domain polymerization leads to constitutive activation of the tyrosine kinase domains, which leads in turn to cell transformation [ 10 12 18 19 ] . Thus, compounds that block TEL-SAM polymerization could be effective in treating these leukemias.

  • There has been no report to link cellular ABL kinase mutation to any cancer patients except BCR-ABL in CML, although the detailed c-Abl function has not been extensively studied in lung cancer patients.

  • The authors proposed that CAP, Ena, and Abl regulate the level and spatial organization of actin in the follicle cells.

  • Ena, a member of the Ena/VASP family proteins that catalyse filament formation, and Abl, a protein kinase that binds CAP in mammalian cells, were found to work with CAP in this process.


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