Example sentences for: abl

How can you use “abl” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Although c-Abl mutations have not been reported in human cancers, c-Abl related protein, ARG (or Abl-2), was shown to be regulated in non-small cell lung cancers by hypermethylation (Dr.

  • These target proteins include the c-Abl tyrosine kinase, the p53 tumor suppressor, the Chk1 and Chk2 serine/threoine kinase, the p34 subunit of replication protein A (RPA), Chk1 serine/threoine kinase and NBS1 kinase which is mutated in human autosomal recessive disease Nijmegan breakage syndrome [ 16 17 18 19 20 21 22 23 ] . Clinical characteristics of AT patients include hypersensitivity to irradiation, thymic dysplasia, immune defects and higher tendency to develop malignant tumor, suggesting that ATM function is critical in DNA damage repair and tumor suppression.

  • The Rlk fusion proteins also failed to efficiently bind SH3 domains from other kinases, including Abl, Csk and Btk.

  • For example, in CML, a commonly found mutation is a C→T single nucleotide change that replaces threonine with isoleucine at position 315 (T315I) in the ABL kinase domain [9,10,11].

  • The new drugs bind to ABL in an “open” conformation, as opposed to imatinib, which binds ABL in a “closed” conformation [12,13].


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