Words similar to aberrantly
Example sentences for: aberrantly
How can you use “aberrantly” in a sentence? Here are some example sentences to help you improve your vocabulary:
Any drop in translation efficiency might alter the counting mechanism and result in aberrantly sized mounds.
In surveying the growing number of studies and claims of new cells that can acquire some type of heart cell phenotype in vitro or in vivo (for a review see [6]), it will become increasingly important to create a set of rigorous criteria that would distinguish between the following: authentic progenitor cells that are already committed to the cardiac lineage; pluripotent stem cells that can infrequently adopt the cardiac phenotype; phenotypic drift of other muscle progenitors with an increased propensity to enter cardiac lineages; and a variety of other cell types that can aberrantly express cardiac markers ectopically or by fusion with neighboring cardiac muscle cells.
Most of the peptides identified so far are either normal self proteins aberrantly expressed in cancer but not in most other adult normal tissues or tissue-specific antigens also expressed in certain types of cancer.
It has been proposed that loss of hERα expression in breast tumors is the result of aberrant RNA processing [ 40 41 42 43 ] . These aberrantly spliced mRNAs, if translated, could lead to truncated receptors with hormone binding but not DNA binding function [ 44 ] . Further, there is evidence for the role of RNA processing in oncogenesis [ 45 46 ] . Many studies, including those on human hnRNP A2/B1 and the CD44 gene, suggest that high fidelity pre-mRNA splicing is critical to normal cellular function and may play a key role in oncogenesis and breast cancer progression [ 47 48 ] . The strong association between nmt55/p54 nrband hERα expression indicates that nmt55/p54 nrbmay be an important marker for breast cancer progression.
Moreover, several recent studies have reported direct mapping of sites phosphorylated by Cdc5/Polo in vitro [ 22 29 32 ] , but in two of these cases the authors relied exclusively on phosphoshift analysis of mutant proteins to confirm that the same sites are phosphorylated in vivo . Given the significant possibility that multiply mutated proteins are not properly phosphorylated in vivo for indirect reasons, or migrate aberrantly upon SDS-PAGE, it may be prudent to perform direct mapping experiments to confirm unambiguously the physiological significance of sites phosphorylated by Cdc5/Polo in vitro .
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