Words similar to aberrant
Example sentences for: aberrant
How can you use “aberrant” in a sentence? Here are some example sentences to help you improve your vocabulary:
Still, because these borrowed, aberrant words represent relatively rare infractions of the time-honored rules of grammar, I doubt that matters will ever reach the point where literate Greeks would be driven to gnashing of teeth and tearing of hair by Greek equivalents of barbarisms such as to you and I and Us teachers are ....
These low-intensity spots are those most aberrant in fold-change and are those for which the magnitude is adjusted most by the model of Newton et al . [ 36].
Infection of cultured podocytes with replication incompetent HIV-1 demonstrated that HIV-1 gene expression leads to the proliferation and dedifferentiation of the infected podocytes [ 6 7 8 ] , recapitulating the phenotypes observed in HIVAN specimens [ 9 10 ] . Similarly, renal expression of replication incompetent HIV-1 proviral transgenes in mice and rats produces a proliferative renal lesion that is indistiguisable both histopathologically and clinically from human HIVAN [ 11 12 13 14 ] . These observations raise the possibility that HIV-1 gene products may interact with mitogenic pathways in infected renal epithelium to cause aberrant cell-cycle engagement.
The pattern of such promoter methylation has been noted to be non-random in various tumor types, while certain genes are commonly methylated in diverse tumor types [ 10 11 ] . The extent of aberrant promoter hypermethylation and its association with loss of gene function in cancer suggests that CpG island methylation is an important mechanism in inactivating tumor suppressor genes (TSGs).
Aberrant promoter methylation changes that occur in cancer are associated with transcriptional repression and loss of function of the methylated gene [ 9 ] . Since we found evidence of down-regulated expression of several methylated genes in CC cell lines, we tested to see if this down-regulation could be reactivated by methylation and HDAC-inhibiting agents.
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