Example sentences for: a-dna

How can you use “a-dna” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The asparagine at position 10 makes contact with DNA in the hSRY-DNA complex [ 24 ] , as does the serine at this position in the NHP6A-DNA complex [ 7 ] . A hydrophobic residue at position 32 that can partially intercalate into DNA plays a role in DNA binding of some sequence-independent HMG-box proteins [ 7 25 26 ] . Position 32 is the hydrophobic residue phenylalanine in TOX, in contrast to the polar residues found at this position in SRY, SOX proteins and LEF-1.

  • The tyrosine at this position (shared with TOX) is a DNA contact in the NHP6A-DNA complex [ 7 ] . Moreover, there is a conserved proline at position 70 of the sequence-specific DNA binding proteins that truncates the third alpha helix of the HMG-box structure allowing additional DNA contacts [ 24 27 28 ] . This proline is absent from TOX and the sequence-independent HMG-box proteins.

  • In the former case, the DNA backbone sites located closest to one another are across the minor groove and separated in sequence by 3 bp [ 28 29 30 ] . The second proposal is supported by a recent 2.2 angstrom NarL-DNA structure for NarL-C-terminal domain complexed to a synthetic 7-2-7 NarL consensus binding site where the protein causes a conformational change of B-DNA to A-DNA (Ann Maris, personal communication).

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