Words similar to a-gvhd
Example sentences for: a-gvhd
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In general, the effects of cytoreductive therapy are not observed after 20 days [ 12 ] . Under proper clinical situation, their association with apoptosis in crypts and pericryptal apoptosis in LP is consistent with A-GVHD in BMT.
As compared to the negative controls (group B- 11% and group C- 14%), crypt apoptosis was frequent in A-GVHD- 91% with statistically significant difference (Table 2K 2 ). With proper clinical history, the diagnosis of A-GVHD can be suggested if apoptosis is observed in and around the crypts.
Sale and colleagues described a comparable feature with "focal increase in density of lymphocytes, plasma cells, and occasional eosinophils in the LP" [ 13 ] . This finding was suggested as a marker for apoptosis favoring the clinical diagnosis of A-GVHD [ 6 ] . They have suggested that the presence of focal periglandular infiltrate warrants a careful search for cryptal apoptosis.
Apoptosis in crypt lining was observed in 91% of group A cases with A-GVHD and demonstrated statistically significant difference as compared to negative control group B and C (p < 0.002, Fisher's exact test) (Table 2K
Other features observed more often in A-GVHD with statistically significant differences as compared to the negative control groups included (Table 2and 4, Figure 2): pericryptal apoptosis adjacent to the crypts in LP, crypt abnormalities (including crypt size variation, crypt dilatation and irregular crypt distribution), reactive changes in LP (including reduced mucosal thickness, muciphages in LP, increased microvessel network, and focal fibrosis), and reactive changes in the surface epithelium with mucin depletion.