Words similar to κb-like

Example sentences for: κb-like

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Subsequently, sequence analysis identified KRC as a member of the ZAS family of proteins which share the ability to bind κB-like motifs [ 15 ] . DNA competition analysis showed that KRC fusion proteins containing the ZAS-C domain bind specifically to both the RSS and to the κB motif [ 14 28 ] . DNA footprinting analysis further showed that KRC/ZAS-C binds to specific nucleotides within the κB and the heptamer of the RSS [ 14 ] . In this study, using a PCR-based DNA-binding site-selection and amplification procedure, we demonstrated that both the N-terminal ZAS-N and the C-terminal ZAS-C domains are able to bind GT-rich DNA sequences, and confirmed that the RSS and κB motifs are the high-affinity targets of KRC.
The cumulative data show that individual ZAS domains bind a κB-like consensus sequence, GGGN (4-5) CC [ 25 ] . However, mouse KRC, αACRYBP1 and mouse MIBP1 have also been shown to bind distinct DNA sequences.
The ability of KRC to promote transcription of target genes has been demonstrated for the S100/mts1 gene by binding at the Sb enhancer motif [ 4 ] . Similarly, binding of κB-like motifs by other ZAS proteins has also been implicated in transcriptional regulation [ 1 2 3 17 ] . Considering KRC's target sequences, the κB motif and the RSS, the two binding domains on a single KRC protein could theoretically bring together cis -acting DNA elements for gene regulation, V(D)J recombination, or both.