Example sentences for: κb
How can you use “κb” in a sentence? Here are some example sentences to help you improve your vocabulary:
The ability of KRC to promote transcription of target genes has been demonstrated for the S100/mts1 gene by binding at the Sb enhancer motif [ 4 ] . Similarly, binding of κB-like motifs by other ZAS proteins has also been implicated in transcriptional regulation [ 1 2 3 17 ] . Considering KRC's target sequences, the κB motif and the RSS, the two binding domains on a single KRC protein could theoretically bring together cis -acting DNA elements for gene regulation, V(D)J recombination, or both.
Our finding that KRC binds to the RSS as well as the κB motif may also provide a link between transcription and recombination in the context of the accessibility model [ 58 59 ] . Enhancer or promoter elements are important for the recombination process in cell lines and animal models [ 60 ] . Similarly, expression of transcription factors, in conjunction with the recombination activating genes, has been shown to induce V(D)J recombination in non-lymphoid tissues by rendering RSS accessible to the recombinase [ 61 ] . The κB motif, first found in the Igκ light chain [ 62 ] , and later in the TCR β2 locus [ 31 ] , has been shown to promote V(D)J recombination by modulating locus accessibility [ 63 ] . In addition to influencing recombination by binding of RSS, KRC binding of the κB motif may modulate accessibility and transcription of target loci.
Thus I-κB is a potential regulatory target for the differential induction of NF-κB.
In addition, Bitko and Barik [ 51 ] have demonstrated that another I-κB protein (I-κBβ) may also contribute via a redox-sensitive pathway to NF-κB activation by RSV.
3a, lanes 7 and 8), nor with the unrelated HIV-1 κB sequence (lane 10).
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