Words similar to α-thalassemia

Example sentences for: α-thalassemia

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Despite this common genetic background, phenotypic expression of sickle cell disease is widely variable, ranging from a mild, asymptomatic course with survival into the sixth or seventh decade to a very severe course with multi-organ damage and early mortality [ 1 ] . Some of the genetic factors contributing to this phenotypic diversity (particularly those linked to the globin genes, i.e. α-thalassemia and β-globin gene cluster haplotypes) have been well recognized [ 2 ] .
In the case of sickle cell disease, only a few genetic factors are known to influence the stroke risk [ 7 ] . For example, α-thalassemia is the only well characterized protective genetic factor [ 7 ] . Thus, genetic factors that lead to the development of cerebrovascular disease and stroke in children with Hb SS are not well understood.
Furthermore, the study of other genetic markers, namely the distribution of β-globin haplotypes and the frequency of deletional α-thalassemia among African-American patients with sickle cell disease from different centers in the United States do not show significant differences arguing against significant population admixture in this group [ 4 11 30 31 ] .