Example sentences for: ydxp
How can you use “ydxp” in a sentence? Here are some example sentences to help you improve your vocabulary:
Moreover, in the absence of stable tyrosine phosphorylation as seen in the Src kinase inactive fusions, v-crk could either induce their phosphorylation, or protect transiently phosphorylated YDXP motifs from dephosphorylation through yet unknown mechanisms.
We then used the 5' and 3' fusions of the Cas SD to determine which motif, YQXP or YDXP, interacts with the v-crk SH2 domain.
Expression of the Src KMfused to the full length Cas SD, 5' N-terminal YQXP motifs or 3' C-terminal YDXP motifs alone demonstrated that these fusions were not stably tyrosine phosphorylated in cells (Fig.
The adaptor protein Cas has several domains that are important for its function, an SH3 domain, a central substrate domain with up to 15 tyrosines that can serve as tyrosine kinase substrates for upstream kinases such as Src and Abl [ 19 42 43 ] , and a C-terminal Src binding domain with PXXP motifs for binding to the SH3 domain of Src, and two tyrosines providing docking sites for the Src SH2 domain upon phosphorylation [ 6 ] . The substrate domain of Cas has two major types of tyrosine motifs that can be phosphorylated and bind downstream effectors, YQXP (4 copies) and YDXP motifs (9 copies), suggesting that at least two classes of downstream effectors, one capable of binding to YDXP motifs and the other capable of binding to YQXP motifs, are assembled by this adaptor protein.
By contrast, co-expression of these fusions along with v-crk results in stable tyrosine phosphorylation of the 3' C-terminal YDXP motifs and the full length Cas SD (carrying both motifs), but not the 5' N-terminal YQXP motifs (Fig.
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