Example sentences for: ydxp
How can you use “ydxp” in a sentence? Here are some example sentences to help you improve your vocabulary:
We transfected v-crk alone or along with the chimera of the attenuated Src kinase domain fused to the C-terminal crk interacting region of the Cas substrate domain (Src*/Cas(3'SD), carrying the YDXP motifs) into Cos-7 cells and immunoprecipitated either the chimera or v-crk and assayed for interacting tyrosine phosphorylated proteins (Fig.
S 325to R 516, 9 YDXP motifs) of Cas amplified.
These data indicate that the v-crk SH2 domain interacts with the C-terminal YDXP motifs, and as suggested by Birge et al, v-crk may be able to protect them from dephosphorylation and/or induces their phosphorylation [ 12 ] . They also suggest that the YQXP motifs may be involved in binding to other intracellular signaling molecules.
We then used the 5' and 3' fusions of the Cas SD to determine which motif, YQXP or YDXP, interacts with the v-crk SH2 domain.
Expression of the Src KMfused to the full length Cas SD, 5' N-terminal YQXP motifs or 3' C-terminal YDXP motifs alone demonstrated that these fusions were not stably tyrosine phosphorylated in cells (Fig.