Words similar to wortmannin

Example sentences for: wortmannin

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We also treated cultured human fetal lung explants with wortmannin, rapamycin or PD98059 in the presence or absence of insulin.
H441 cells resemble bronchiolar epithelial Clara cells in phenotype and produce both SP-A and SP-B mRNA and protein [ 14 ] . The hormonal regulation of SP-A and SP-B gene expression in H441 cells is similar to that observed in differentiated type II cells in human fetal lung explants [ 6 7 15 16 ] . We treated H441 cells with the four inhibitors of signal transduction: wortmannin, LY294002, rapamycin and PD98059, to elucidate which signaling pathways are activated when insulin inhibits SP-A gene expression.
However wortmannin, at concentrations of 5-200 nM, abolished the insulin-mediated inhibition of SP-A mRNA levels at all concentrations tested (5-200 nM, Fig.
LDH activity was not different from controls in cells treated for 12 to 16 hours with either 200 nM wortmannin, 5 μM LY294002, 20 nM rapamycin, or 10 μM PD98059 (data not shown).
2shows that wortmannin (100 nM) and rapamycin (50 nM) both abolished the insulin-mediated inhibition of SP-A gene expression.