Words similar to wortmannin

Example sentences for: wortmannin

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Wortmannin, added alone, did not significantly alter SP-A mRNA levels at any concentration tested (Fig.
Wortmannin is a fungal metabolite that is a relatively selective inhibitor of PI 3-kinase with a half-maximal inhibition (IC 50 ) less than 5 nM [ 11 ] . In the wortmannin experiments, media were changed every 2 hours for a total of 12 hours in all of the conditions because wortmannin is unstable in solution at physiological pH [ 19 ] . The shorter incubation time with insulin in the wortmannin experiments resulted in a decreased inhibitory effect of insulin, i.e., an ~22% inhibition of SP-A mRNA levels (Fig.
To confirm the inhibitory effect of wortmannin on insulin action, a structurally different PI 3-kinase inhibitor, LY294002, was used.
On the last day of culture, explants were pretreated with signal transduction inhibitors, either wortmannin, rapamycin or PD98059, for 30-60 min and then further treated with insulin (2.
Porcine insulin was purchased from Calbiochem (San Diego, CA, USA), wortmannin, LY294002, and rapamycin were purchased from Sigma-Aldrich Company (St.