Words similar to wortmannin

Example sentences for: wortmannin

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Wortmannin is a fungal metabolite that is a relatively selective inhibitor of PI 3-kinase with a half-maximal inhibition (IC 50 ) less than 5 nM [ 11 ] . In the wortmannin experiments, media were changed every 2 hours for a total of 12 hours in all of the conditions because wortmannin is unstable in solution at physiological pH [ 19 ] . The shorter incubation time with insulin in the wortmannin experiments resulted in a decreased inhibitory effect of insulin, i.e., an ~22% inhibition of SP-A mRNA levels (Fig.
Wortmannin, LY294002, rapamycin and PD98059 were reconstituted in dimethyl sulphoxide as 1 mM, 50 mM, 50 μM and 10 mM stock solutions, respectively, and stored at -80°C in aliquots.
We found that wortmannin and rapamycin had no effect on basal SP-A mRNA levels, at any concentration tested.
Porcine insulin was purchased from Calbiochem (San Diego, CA, USA), wortmannin, LY294002, and rapamycin were purchased from Sigma-Aldrich Company (St.
Treatment of Jurkat cells with Wortmannin had no effect on Rlk association with RAFTs (Fig.