Words similar to wnt-

Example sentences for: wnt-

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As expected, phosphorylated AKT was undetectable in hyperplastic ducts, in tumors from Wnt-1 TG, Pten +/+ mice, and tumors from Wnt-1 TG, Pten +/- mice that retained the wild type allele (Fig.
In initial experiments, we found that Wnt-3A protein elevates the levels of β-catenin 5-10 fold (Figure 4); and that a transiently transfected TCF reporter construct is activated 3-4 fold (not shown).
As in the case of Wnt-1 TG male mice without Pten mutations, the majority of tumors (14/22) arose in the salivary tissue; only a small number of tumors (2/22) were mammary in origin, and, interestingly, some (6/22) were bilateral or unilateral muzzle tumors of epithelial origin, similar histopathologically to lesions found in mammary and salivary tissues.
To date, heterozygous inactivation of any of the other tumor suppressor genes implicated in breast cancer, including P53, Brca1, Brca2 , and Rb , has failed to cooperate with Wnt-1 in promoting the appearance of mammary tumors [reviewed in ref.
Mouse L cells secreting Wnt-3A were established in our lab, by transfecting expression constructs in which the Wnt-3A cDNA [ 34 ] is driven by the PGK promoter.