Example sentences for: wnt

How can you use “wnt” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Together with the DNA binding protein TCF, β-catenin activates expression of Wnt target genes.

  • We tested human teratocarcinoma cells (NCCIT) cells for a Wnt response.

  • However, Wnt signaling also promotes the expression of such genes as Cyclin D1 [ 22 ] and MYC [ 23 ] , which are not elevated by BMP.

  • APC mutations have been identified in medulloblastoma cell lines and up to 4% of sporadic medulloblastomas [ 16 17 ] . Furthermore, point mutations or small deletions in β- catenin exon 3 have been identified in 5-10% of sporadic medulloblastomas and in supratentorial primitive neuroectodermal tumors (PNETs) [ 17 18 19 ] . Finally, large deletions in AXIN were recently found in 12% of sporadic medulloblastomas [ 20 ] . In the absence of Wnt signaling β-catenin is sequestered in the cytoplasm, and nuclear translocation of β-catenin has been used to monitor activation of the Wnt pathway in a number of different tumor types.

  • In the Wnt target gene promoters that are functionally mapped (MSX1, MSX2, ID2, ID3, Follistatin, REST/NRSF, Versican) we invariably found TCF binding sites.


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