Example sentences for: wnt

How can you use “wnt” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • LRPs have been shown to bind to Wnt/Wg through the first and second EGF repeats of their extracellular domain [ 11 ] . Our unpublished work in mammalian cells and results from others [ 11 13 ] demonstrate that the expression of LRP6 or an aminoterminal truncation mutant (LRP6ΔN), which should no longer bind to Wnt, can activate the Wnt signaling pathway.

  • The overall pattern of gene expression observed in response to Wnt has important implications for the role of Wnt signaling in development and cancer.

  • The mechanism by which the Wnt signal is transduced through its transmembrane receptors is not clear.

  • Mis-regulation of Wnt signaling leads to the development of several human cancers, including colon carcinomas and melanoma [ 1 ] . Canonical Wnt signaling initiates in the binding of a Wnt ligand to its cell surface receptor, members of the frizzled gene family, along with the co-receptor LRP5/6 [ 2 3 ] , leading to changes in the activities of cytoplasmic effectors resulting in the stabilization of beta-catenin protein.

  • We focused on two genes that showed differential regulation by Wnt-1 and Wnt-5a since their regulation was reproducible using several methods to activate the Wnt signaling pathways.


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