Example sentences for: wnt

How can you use “wnt” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Wnt signal transduction proceeds through a complex series of protein interactions, initiated by binding of the Wnt protein to cell surface receptors (Frizzled and LRP [ 3 4 5 ] ) which generates a signal to downstream components.

  • While the functions of Fz and Dsh remain to be clarified, it is possible that upon Wnt signaling, Fzs recruit Dsh to the membrane and Dsh brings Axin to the carboxyterminus of LRPs.

  • Furthermore, it was reported that LRP signaling can be activated in a Dsh - independent fashion [ 14 ] . These data suggest that Wnt/Wg could signal through LRP directly to the β-catenin destruction complex in a Fz- and Dsh-independent fashion.

  • The lack of aberrant neuronal proliferation in our mice suggests that differentiated neurons may not be as susceptible to the mitogenic effects of Wnt signaling as are neuroepithelial progenitor cells [ 22 ] .

  • Moreover, Frizzled receptors, Versican and other proteoglycans which contribute to Wnt protein activity are also controlled by Wnt signaling, as previously described in Drosophila [ 28 29 ] . At the level of transcriptional regulation, we found up-regulation of CBP/P300, which partners with β-catenin [ 30 31 ] but also TLE/Groucho, which is an inhibitor of TCF function [ 32 ] . These responses suggest a rich system of homeostasis and feedback control mechanisms, but they complicate the interpretation of experimental studies of Wnt signal transduction in which the time course of induction cannot be controlled easily.


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