Example sentences for: wky
How can you use “wky” in a sentence? Here are some example sentences to help you improve your vocabulary:
Interestingly, a similar whole-body accumulation of plant sterols, less severe than in human sitosterolemia, has been reported recently in SHR, SHRSP and WKY rats, but not in the other genetically related rat strains, such as SD, Wistar and WKA rats [ 16 ] . These rats exhibit defects at two levels: increased absorption of sterols (plant and animal) at the intestinal level and decreased excretion of sterols into bile [ 16 ] . The higher sterol absorption in the intestine and the lower biliary excretion of plant sterols in these rat strains led us to hypothesise that Abcg5 or Abcg8 gene mutations may be responsible for the sitosterolemia observed in these hypertensive rats.
WKY, SHR, SHRSP and GH rats are homozygous, Sprague Dawley and WKA strains wild-type and the Wistar sample heterozygous for this polymorphism (Fig.
The GH rat was selected for systolic hypertension that increased with successive generations and maintained through filial matings [ 45 ] . In view of this, the Gly583Cys missense mutation of Abcg5 might result from occurrence of a de novo mutation during breeding at the stage of developing inbred WKY strains and propagated into the SHR and SHRSP lines.
Evidence that sterolin-1 and sterolin-2 may heterodimerize has now been presented, based upon in vitro analyses [ 13 ] . However, our preliminary analyses of immunohistochemistry, using an antibody to sterolin-1 suggests that the pattern of expression in the liver and intestine is similar for both SD as well as WKY or SHR rats (Fig.
Abcg8 may have resulted from acquisition of a foreign chromosomal fragment during the Wistar rat strain breeding and established as homozygous change in the WKY, SHR and SHRSP, as well as GH rat strains.
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