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Example sentences for: wky

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Interestingly, the message for LDL-R was reduced in both WKY and SHR livers.
This 'mutation' was only detected in SHR, SHRSP and WKY rats and was present in all of these strains as a homozygous change (Table 5).
A number of different groups have reported that genetically hypertensive strains of rats (SHR, SHRSP, WKY) have elevated levels of plasma sitosterol [ 15 16 17 18 19 20 21 22 ] . Although the WKY strain is not considered hypertensive, dietary alterations involving plant sterols appear to increase blood pressure in this strain [ 21 ] . We screened two commercially available hypertensive rats, as well as a 'genetically hypertensive' strain, GH, for plasma plant sterol levels and compared these to two control strains, Sprague-Dawley and Wistar (Table 4).
The WKY rat also carries this mutation and a high dietary intake of phytosterols will also increase the blood pressure and decrease the density of platelets, though to a lower extent than that observed in SHRSP rats [ 20 ] . These data support a pathological role of elevated plant sterols in these rats and support the notion that the STSL loci evolved to not only allow for the excretion of cholesterol into bile, but also to keep 'xeno-sterols' from accumulating in the body.
While this manuscript was in review, Scoggan et al also reported identifying Gly583Cys alteration in Abcg5 of SHR, SHRP and WKY rats [ 49 ] .