Example sentences for: wka
How can you use “wka” in a sentence? Here are some example sentences to help you improve your vocabulary:
The DNA samples from the following rat strains were used: Sprague Dawley (SD, Charles River Laboratories, Wilmington, MA), Wistar (Sea: Wistar, Outbred, SPF, Seac Yoshitomi) and WKA (WKA/Sea, inbred, SPF, Seac Yoshitomi), WKY (WKY/NCrj, inbred, SPF, Charles River Japan, Kanagawa, Japan or Charles River, Wilmington, MA), SHR/Crl (Charles River, Wilmington, MA), SHRSP (SHRSP/Sea, inbred, SPF, Seac Yoshitomi, Fukuoka, Japan), GH and BN.
The SHR strain was derived by selective inbreeding from the Kyoto outbred Wistar colony, and both SHR and SHRSP, as well as WKY strains have been maintained over many generations through brother-sister matings http://rgd.mcw.edu/tools/strains [ 43 44 ] . Healthy WKA and GH rat strains were also generated from outbred Wistar rat strains, but these strains were isolated independently in Japan and New Zealand, respectively (and maintained at other sites as well).
Interestingly, a similar whole-body accumulation of plant sterols, less severe than in human sitosterolemia, has been reported recently in SHR, SHRSP and WKY rats, but not in the other genetically related rat strains, such as SD, Wistar and WKA rats [ 16 ] . These rats exhibit defects at two levels: increased absorption of sterols (plant and animal) at the intestinal level and decreased excretion of sterols into bile [ 16 ] . The higher sterol absorption in the intestine and the lower biliary excretion of plant sterols in these rat strains led us to hypothesise that Abcg5 or Abcg8 gene mutations may be responsible for the sitosterolemia observed in these hypertensive rats.
WKY, SHR, SHRSP and GH rats are homozygous, Sprague Dawley and WKA strains wild-type and the Wistar sample heterozygous for this polymorphism (Fig.
However, one change, G1754T in exon 12 was identified that led to a coding change of Gly583Cys in sterolin-1 ( Abcg5 ). This change was found only in rat strains that were confirmed to be sitosterolemic (WKY, SHR and SHRSP), but not in any of the other strains screened (SD, Wistar, WKA, GH or BN).
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