Words similar to whole-genome
Example sentences for: whole-genome
How can you use “whole-genome” in a sentence? Here are some example sentences to help you improve your vocabulary:
Release 3 of the D. melanogaster genomic sequence was generated using bacterial artificial chromosome (BAC) clones that formed a complete tiling path across the genome, as well as whole-genome shotgun sequencing reads [ 10].
In conclusion, we believe that our dual approach of a candidate gene and whole-genome association study will yield important information on genetic risk factors for cerebrovascular disease in sickle cell disease.
We constructed a high-resolution RH map (likelihood ratio of greater than 300:1 over the next likely order) with the medium-resolution G3 and high-resolution TNG whole-genome RH panels (Figure 1).
Initial simulation estimates based on monotonic population expansion suggested that useful LD was unlikely to extend beyond 3 kb, implying a number of 500,000 SNPs necessary for a whole-genome scan [ 32 ] . Another study looking at real data found that LD extended over much larger distances and arrived at an estimate as small as 30,000 SNPs, or 1 SNP per 100 kb [ 33 ] . Recent evidence suggests that the genome consists of blocks of high LD (haplotype blocks) separated by recombination hot spots [ 34 ] . Within each block, a limited number of common haplotypes (three to five) typically capture about 90% of all chromosomes, which means that a reduced number of SNPs would be needed to characterize these haplotypes [ 35 ] . Thus, the recently initiated construction of a haplotype map of the human genome may facilitate selection of SNP markers for genomewide association studies like ours.
Whole-genome shotgun sequencing of Saccharomyces bayanus , S. mikatae , and S. paradoxus has been previously described [ 26 ] . All are highly related to S. cerevisiae , as they are grouped within the sensu stricto branch of the Saccharomyces genus [ 28 ] . Intergenic regions were aligned using CLUSTALW as described [ 26 ] and are available from the Yeast Comparative Genomics website [ 42 ] . A total of 4,101 CLUSTALW alignments were analyzed.
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